The Role of Genetic Variants in the Susceptibility of Noise-Induced Hearing Loss

Noised-induced hearing loss (NIHL) is an acquired, progressive neurological damage caused by exposure to intense noise in various environments including industrial, military and entertaining settings. The prevalence of NIHL is much higher than other occupational injuries in industrialized countries....

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Published inFrontiers in cellular neuroscience Vol. 16; p. 946206
Main Authors Chen, Xue-min, Xue, Xin-miao, Yu, Ning, Guo, Wei-wei, Yuan, Shuo-long, Jiang, Qing-qing, Yang, Shi-ming
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Research Foundation 12.07.2022
Frontiers Media S.A
Subjects
Apoptosis
Cellular Neuroscience
Chemokines
Cilia
Cytokines
DNA damage
DNA repair
Environmental conditions
Flow velocity
genes
Genetic diversity
Genetic factors
genetic variants
Hair
Hearing loss
Hearing protection
Heat shock proteins
Hsp70 protein
Kinases
Metabolism
Metabolites
Noise
noise prevention
noised-induced hearing loss
Oxidative stress
Pathogenesis
Population studies
Protein structure
Sound
susceptibility
Tinnitus
Tumor necrosis factor-TNF
genetic variants
noise prevention
noised-induced hearing loss
susceptibility
genes
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Summary:Noised-induced hearing loss (NIHL) is an acquired, progressive neurological damage caused by exposure to intense noise in various environments including industrial, military and entertaining settings. The prevalence of NIHL is much higher than other occupational injuries in industrialized countries. Recent studies have revealed that genetic factors, together with environmental conditions, also contribute to NIHL. A group of genes which are linked to the susceptibility of NIHL had been uncovered, involving the progression of oxidative stress, potassium ion cycling, cilia structure, heat shock protein 70 (HSP70), DNA damage repair, apoptosis, and some other genes. In this review, we briefly summarized the studies primary in population and some animal researches concerning the susceptible genes of NIHL, intending to give insights into the further exploration of NIHL prevention and individual treatment.
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Edited by: Zhiwu Huang, Shanghai Jiao Tong University, China
These authors have contributed equally to this work
This article was submitted to Cellular Neuropathology, a section of the journal Frontiers in Cellular Neuroscience
Reviewed by: Hyeong-Geug Kim, Purdue University Indianapolis, United States; Boshen Wang, Southeast University, China
ISSN:1662-5102
1662-5102
DOI:10.3389/fncel.2022.946206