Anti-Diabetes, Anti-Gout, and Anti-Leukemia Properties of Essential Oils from Natural Spices Clausena indica , Zanthoxylum rhetsa , and Michelia tonkinensis
Essential oils (EOs) of fruits, fruits, and seeds were analyzed for their phytochemical profiles and biological activities, including anti-diabetes, anti-gout, and anti-leukemia properties. Sixty-six volatile compounds were identified by gas chromatography-mass spectrometry (GC-MS), in which, myrist...
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Published in | Molecules (Basel, Switzerland) Vol. 27; no. 3; p. 774 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
MDPI AG
25.01.2022
MDPI |
Subjects | |
Online Access | Get full text |
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Summary: | Essential oils (EOs) of
fruits,
fruits, and
seeds were analyzed for their phytochemical profiles and biological activities, including anti-diabetes, anti-gout, and anti-leukemia properties. Sixty-six volatile compounds were identified by gas chromatography-mass spectrometry (GC-MS), in which, myristicin (68.3%), limonene (44.2%), and linalool (49.3%) were the most prominent components of EOs extracted from
,
, and
, respectively. In addition, only EOs from
inhibited the activities of all tested enzymes comprising α-amylase (IC
= 7.73 mg/mL), α-glucosidase (IC
= 0.84 mg/mL), and xanthine oxidase (IC
= 0.88 mg/mL), which are related to type 2 diabetes and gout. Remarkably, all EOs from
,
(IC
= 0.73 mg/mL), and
(IC
= 1.46 mg/mL) showed a stronger anti-α-glucosidase ability than acarbose (IC
= 2.69 mg/mL), a known anti-diabetic agent. Moreover, the growth of leukemia cell Meg-01 was significantly suppressed by all EOs, of which, the IC
values were recorded as 0.32, 0.64, and 0.31 mg/mL for EOs from
,
, and
, respectively. As it stands, this is the first report about the inhibitory effects of EOs from
and
fruits, and
seeds on the human leukemia cell line Meg-01 and key enzymes linked to diabetes and gout. In conclusion, the present study suggests that EOs from these natural spices may be promising candidates for pharmaceutical industries to develop nature-based drugs to treat diabetes mellitus or gout, as well as malignant hematological diseases such as leukemia. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1420-3049 1420-3049 |
DOI: | 10.3390/molecules27030774 |