Nanomaterials for Wound Dressings: An Up-to-Date Overview

• Published in: Molecules (Basel, Switzerland) Vol. 25; no. 11; p. 2699
• Main Authors: Stoica, Alexandra Elena, Chircov, Cristina, Grumezescu, Alexandru Mihai
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 10.06.2020; MDPI
• Subjects: Alginates; Alginic acid; Bandages, Hydrocolloid; Biocompatibility; Biomaterials; Biomedical materials; bionanomaterial; Clinical trials; Humans; Multilayers; Nanomaterials; nanomedicine; Nanoparticles; Nanostructures - chemistry; Nanotechnology; R&D; Regenerative medicine; Research & development; Review; semi-permeable films; Skin; Tissue engineering; wound dressings; Wound Healing; bionanomaterial; hydrocolloid dressings; wound dressings; non-adherent contact layer dressings; nanotechnology; nanomedicine; nanomaterials; alginates dressings; semi-permeable films; multilayer dressings; semipermeable foam dressings; hydrogel dressings
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules25112699

As wound healing continues to be a challenge for the medical field, wound management has become an essential factor for healthcare systems. Nanotechnology is a domain that could provide different new approaches concerning regenerative medicine. It is worth mentioning the importance of nanoparticles, which, when embedded in biomaterials, can induce specific properties that make them of interest in applications as materials for wound dressings. In the last years, nano research has taken steps to develop molecular engineering strategies for different self-assembling biocompatible nanoparticles. It is well-known that nanomaterials can improve burn treatment and also the delayed wound healing process. In this review, the first-line of bioactive nanomaterials-based dressing categories frequently applied in clinical practice, including semi-permeable films, semipermeable foam dressings, hydrogel dressings, hydrocolloid dressings, alginate dressings, non-adherent contact layer dressings, and multilayer dressings will be discussed. Additionally, this review will highlight the lack of high-quality evidence and the necessity for future advanced trials because current wound healing therapies generally fail to provide an excellent clinical outcome, either structurally or functionally. The use of nanomaterials in wound management represents a unique tool that can be specifically designed to closely reflect the underlying physiological processes in tissue repair.