NFAT, immunity and cancer: a transcription factor comes of age

Nuclear factor of activated T cells (NFAT) was first identified more than two decades ago as a major stimulation-responsive DNA-binding factor and transcriptional regulator in T cells. It is now clear that NFAT proteins have important functions in other cells of the immune system and regulate numero...

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Bibliographic Details
Published inNature reviews. Immunology Vol. 10; no. 9; pp. 645 - 656
Main Authors Müller, Martin R, Rao, Anjana
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.09.2010
Subjects
Animals
Cancer
Cellular proteins
Chemical properties
Development and progression
Genetic aspects
Health aspects
Humans
Immune system
Immunity
Immunology
Kinases
Lymphocytes
Neoplasms - immunology
Neoplasms - metabolism
NFATC Transcription Factors - immunology
Phosphorylation
Proteins
Signal Transduction - immunology
T cells
T-Lymphocytes - immunology
T-Lymphocytes - metabolism
Transcription factors
Transcription Factors - immunology
Transcription, Genetic
Vertebrates
United States
La Jolla California
United States > US
Massachusetts
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Summary:Nuclear factor of activated T cells (NFAT) was first identified more than two decades ago as a major stimulation-responsive DNA-binding factor and transcriptional regulator in T cells. It is now clear that NFAT proteins have important functions in other cells of the immune system and regulate numerous developmental programmes in vertebrates. Dysregulation of these programmes can lead to malignant growth and cancer. This Review focuses on recent advances in our understanding of the transcriptional functions of NFAT proteins in the immune system and provides new insights into their potential roles in cancer development.
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ISSN:1474-1733
1474-1741
DOI:10.1038/nri2818