Acute Kidney Injury in a Patient with Polyarteritis Nodosa and Multiple Myeloma

• Published in: Internal Medicine Vol. 53; no. 3; pp. 263 - 267
• Main Authors: Yokota, Kazuhiro, Inoue, Tsutomu, Akiyama, Yuji, Kajiyama, Hiroshi, Asanuma, Yu Funakubo, Arai, Eiichi, Suzuki, Hiromichi, Mimura, Toshihide
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society of Internal Medicine 01.01.2014
• Subjects: acute kidney injury; Acute Kidney Injury - complications; Acute Kidney Injury - diagnosis; double filtration plasmapheresis; Fatal Outcome; Humans; Male; Middle Aged; multiple myeloma; Multiple Myeloma - complications; Multiple Myeloma - diagnosis; polyarteritis nodosa; Polyarteritis Nodosa - complications; Polyarteritis Nodosa - diagnosis
• ISSN: 0918-2918; 1349-7235
• DOI: 10.2169/internalmedicine.53.1120

We herein report the case of a Japanese man with polyarteritis nodosa (PAN) accompanied by multiple myeloma (MM). The patient was diagnosed with PAN. Concurrently, IgG kappa paraprotein was detected, and bone marrow changes indicative of MM were observed. Prednisolone (PSL) administered at a dose of 30 mg/day was initiated; however, the serum creatinine level increased. In spite of increasing the dose of PSL to 45 mg/day and initiating treatment with double filtration plasmapheresis, the patient's renal dysfunction continued to progress and haemodialysis was introduced. He died from pneumonia 12 months after admission. We conclude that renal failure is an important risk factor in the prognosis of PAN accompanied by MM.