The Emerging Role of B Cells in Tumor Immunity

There is increasing evidence supporting a role for B cells in tumor immunology. Paraneoplastic syndromes occurring before a cancer diagnosis have pointed to the potential for harnessing the humoral immune response for early cancer detection. The presence of tumor-infiltrating B lymphocytes has been...

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Published inCancer research (Chicago, Ill.) Vol. 76; no. 19; pp. 5597 - 5601
Main Authors Tsou, Peiling, Katayama, Hiroyuki, Ostrin, Edwin J, Hanash, Samir M
Format Journal Article
LanguageEnglish
Published United States 01.10.2016
Subjects
Autoantibodies - analysis
Autoantibodies - therapeutic use
Autoimmunity
B-Lymphocytes - immunology
Biomarkers
Humans
Lymphocytes, Tumor-Infiltrating - immunology
Neoplasms - immunology
Tumor Microenvironment
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Summary:There is increasing evidence supporting a role for B cells in tumor immunology. Paraneoplastic syndromes occurring before a cancer diagnosis have pointed to the potential for harnessing the humoral immune response for early cancer detection. The presence of tumor-infiltrating B lymphocytes has been linked to a favorable clinical outcome in many types of cancers. However, B cells represent a heterogeneous population with functionally distinct subsets, and the balance among subtypes impacts tumor development. Here, we review recent findings related to B cells and to the humoral immune response in cancer and their translational significance. Cancer Res; 76(19); 5597-601. ©2016 AACR.
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ISSN:0008-5472
1538-7445
DOI:10.1158/0008-5472.can-16-0431