Recent Achievements in Medicinal and Supramolecular Chemistry of Betulinic Acid and Its Derivatives

• Published in: Molecules (Basel, Switzerland) Vol. 24; no. 19; p. 3546
• Main Authors: Bildziukevich, Uladzimir, Özdemir, Zülal, Wimmer, Zdeněk
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 30.09.2019; MDPI
• Subjects: Acids; Acquired immune deficiency syndrome; adme parameters; AIDS; antitumor activity; antiviral activity; Apoptosis; betulinic acid; Binding sites; Bioavailability; Chemical Phenomena; Cytotoxicity; Drug resistance; Edema; Hepatitis B; HIV; Human immunodeficiency virus; Humans; Inflammation; Investigations; Kinases; Peptides; physicochemical parameters; Phytochemicals - chemistry; Phytochemicals - isolation & purification; Phytochemicals - pharmacology; Proteins; Review; structural modification; Structure-Activity Relationship; supramolecular self-assembly; Triterpenes - chemistry; Triterpenes - isolation & purification; Triterpenes - pharmacology; Tumor necrosis factor-TNF; Viruses; physicochemical parameters; antitumor activity; supramolecular self-assembly; ADME parameters; antiviral activity; betulinic acid; cytotoxicity; structural modification
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules24193546

The subject of this review article refers to the recent achievements in the investigation of pharmacological activity and supramolecular characteristics of betulinic acid and its diverse derivatives, with special focus on their cytotoxic effect, antitumor activity, and antiviral effect, and mostly covers a period 2015–2018. Literature sources published earlier are referred to in required coherences or from historical points of view. Relationships between pharmacological activity and supramolecular characteristics are included if such investigation has been done in the original literature sources. A wide practical applicability of betulinic acid and its derivatives demonstrated in the literature sources is also included in this review article. Several literature sources also focused on in silico calculation of physicochemical and ADME parameters of the developed compounds, and on a comparison between the experimental and calculated data.