Age, atherosclerosis and type 2 diabetes reduce human mesenchymal stromal cell-mediated T-cell suppression

To this end human MSCs were isolated from adipose tissue and the MSC:CD4(+) T-cell suppression was assessed in a co-culture system. In summary, this study demonstrates that advanced age, atherosclerosis and type 2 diabetes mellitus reduce the functional potency of MSCs. Optimizing the criteria for t...

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Bibliographic Details
Published inStem cell research & therapy Vol. 6; no. 1; p. 140
Main Authors Kizilay Mancini, Ozge, Shum-Tim, Dominique, Stochaj, Ursula, Correa, José A, Colmegna, Inés
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 08.08.2015
BioMed Central
Subjects
Adipose Tissue - cytology
Age Factors
Aged
Atherosclerosis
Atherosclerosis - pathology
CD4-Positive T-Lymphocytes - cytology
CD4-Positive T-Lymphocytes - immunology
CD4-Positive T-Lymphocytes - metabolism
CD8-Positive T-Lymphocytes - cytology
CD8-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - metabolism
Cell Proliferation
Cells, Cultured
Coculture Techniques
Diabetes Mellitus, Type 2 - pathology
Female
Health aspects
Heart diseases
Humans
Linear Models
Male
Mesenchymal Stromal Cells - cytology
Mesenchymal Stromal Cells - metabolism
Methods
Middle Aged
Patient outcomes
Physiological aspects
Severity of Illness Index
Short Report
Stem cells
T cells
Type 2 diabetes
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Summary:To this end human MSCs were isolated from adipose tissue and the MSC:CD4(+) T-cell suppression was assessed in a co-culture system. In summary, this study demonstrates that advanced age, atherosclerosis and type 2 diabetes mellitus reduce the functional potency of MSCs. Optimizing the criteria for the selection of MSC donors could enhance the results of cell-based therapies.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1757-6512
1757-6512
DOI:10.1186/s13287-015-0127-9