Plasma disposition of flumequine in common carp ( Cyprinus carpio L., 1758), African catfish ( Clarias gariepinus Burchell, 1822) and European eel ( Anguilla anguilla L., 1758) after a single peroral administration

• Published in: Aquaculture Vol. 123; no. 1; pp. 21 - 30
• Main Authors: van der Heijden, M.H.T., Keukens, H.J., van den Nieuwboer, W.H.F.X., Mengelers, M.J.B., Boon, J.H.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 1994; Elsevier Science; Elsevier Sequoia S.A
• Subjects: aliment medicamenteux; Anguilla anguilla; anguilla genero; anguilla genre; anguilla genus; Animal aquaculture; Animal productions; Aquaculture; Aquaculture and Fisheries; Aquacultuur en Visserij; Biological and medical sciences; clarias; Clarias gariepinus; cyprinus; Cyprinus carpio; Drug therapy; drugs; Fish; Freshwater; Fundamental and applied biological sciences. Psychology; Leerstoelgroep Aquacultuur en Visserij; Marine biology; medicament; medicamentos; medicated feed; piensos medicinales; Pisciculture; Vertebrate aquaculture; WIAS; Freshwater environment; Vertebrata; Anguilla anguilla; Pisces; Pisciculture; Clarias gariepinus; Cyprinus carpio; Antibacterial agent; Pharmacokinetics; Route of administration
• ISSN: 0044-8486; 1873-5622
• DOI: 10.1016/0044-8486(94)90116-3

The disposition of perorally administered flumequine in plasma was compared between common carp ( Cyprinus carpio L., 1758), African catfish ( Clarias gariepinus Burchell, 1822) and European eel ( Anguilla anguilla L., 1758) respectively, at a dose of 18 mg·kg −1 body weight. All species showed rapid absorption followed by biphasic plasma depletion. Significant interspecies differences were observed for most of the determined pharmacokinetic parameters. Mean highest plasma flumequine concentrations were 6136 ng·ml −1 in carp, 4074 ng ml −1 in eel and 1179 ng·ml −1 in catfish. Mean distribution and elimination half-lives were 3.4 and 104.3 h for carp, 7.3 and 59.5 h for catfish and 56.7 and 451.2 h for eel. To achieve equivalent drug efficacy and to minimize the probability of residues as a result of medication, dosage regimes and withdrawal periods should be adapted for each species.