Calcium Ion Requirement in Lymphocyte Stimulation

The requirement for Ca2+ and Ca2+ uptake were determined both at the initial step and during the phase of commitment. The onset of RNA and protein synthesis, which occurred around 12h after stimulation, were not delayed by the early 12h Ca2+ depletion. On the other hand, DNA synthesis was delayed by...

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Published inCYTOLOGIA Vol. 54; no. 3; pp. 473 - 476
Main Authors Komada, Hiroshi, Nakabayashi, Hiroshi, Takanari, Hideki, Izutsu, Kosaku
Format Journal Article
LanguageEnglish
Published Tokyo Japan Mendel Society, International Society of Cytology 1989
Japan Mendel Society
Japan Science and Technology Agency
Subjects
Biological and medical sciences
Cell cycle, cell proliferation
Cell physiology
Fundamental and applied biological sciences. Psychology
Molecular and cellular biology
Human
Cell proliferation
Lymphocyte transformation test
Amygdala
Stimulation
Calcium Ions
Child
Lymphocyte
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Summary:The requirement for Ca2+ and Ca2+ uptake were determined both at the initial step and during the phase of commitment. The onset of RNA and protein synthesis, which occurred around 12h after stimulation, were not delayed by the early 12h Ca2+ depletion. On the other hand, DNA synthesis was delayed by both early and late Ca2+ depletion. The enhancement of Ca+2 uptake was observed at each stage. We concluded that Ca2+ is required for both the stages and that Ca2+ is more necessary for the time of commitment than it is for the early phase of lymphocyte stimulation.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:0011-4545
1348-7019
DOI:10.1508/cytologia.54.473