Cellular communications in bone homeostasis and repair
Cellular communication between the bone component cells osteoblasts, osteocytes and (pre-)osteoclasts is essential for bone remodeling which maintains bone integrity. As in the remodeling of other organs, cell death is a trigger for remodeling of bone. During the systematic process of bone remodelin...
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Published in | Cellular and molecular life sciences : CMLS Vol. 67; no. 23; pp. 4001 - 4009 |
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Main Author | |
Format | Journal Article |
Language | English |
Published |
Basel
Basel : SP Birkhäuser Verlag Basel
01.12.2010
SP Birkhäuser Verlag Basel Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | Cellular communication between the bone component cells osteoblasts, osteocytes and (pre-)osteoclasts is essential for bone remodeling which maintains bone integrity. As in the remodeling of other organs, cell death is a trigger for remodeling of bone. During the systematic process of bone remodeling, direct or indirect cell-cell communication is indispensable. Thus, osteoblasts induce migration and differentiation of preosteoclasts, which is followed by bone resorption (by mature multinuclear osteoclasts). After completion of bone resorption, apoptosis of mature osteoclasts and differentiation of osteoblasts are initiated. At this time, the osteoblasts do not support osteoclast differentiation but do support bone formation. Finally, osteoblasts differentiate to osteocytes in bone or to bone lining cells on bone surfaces. In this way, old bone areas are regenerated as new bone. In this review the role of cell-cell communication in bone remodeling is discussed. |
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Bibliography: | http://dx.doi.org/10.1007/s00018-010-0479-3 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 1420-682X 1420-9071 |
DOI: | 10.1007/s00018-010-0479-3 |