Synthesis of Indoles Using Visible Light: Photoredox Catalysis for Palladium-Catalyzed CH Activation

A combined palladium‐ and photoredox‐catalyzed CH olefination enables the synthesis of indoles. By using visible light, the direct CH activation of aromatic enamines can be achieved and a variety of indole derivatives can be obtained in good yields under mild reaction conditions. Coupling without...

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Bibliographic Details
Published inAngewandte Chemie International Edition Vol. 53; no. 48; pp. 13264 - 13268
Main Authors Zoller, Jochen, Fabry, David C., Ronge, Meria A., Rueping, Magnus
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 24.11.2014
WILEY‐VCH Verlag
Wiley
Subjects
Activation
Catalysis
Chemistry
Chemistry, Multidisciplinary
CH functionalization
Derivatives
Heck reaction
Indoles
Indoles - chemical synthesis
Joining
Light
Molecular Structure
Palladium - chemistry
photocatalysis
Physical Sciences
Science & Technology
superoxide
Synthesis
ROOM-TEMPERATURE
ELECTRON-WITHDRAWING SUBSTITUENTS
BOND-FORMING REACTIONS
Heck reaction
HECK REACTIONS
C-H functionalization
AROMATIC-SUBSTITUTION
OLEFINS
OXIDATIVE CYCLIZATION
photocatalysis
superoxide
EFFICIENT
ALKENYLATION
MOLECULAR-OXYGEN
CH functionalization
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Summary:A combined palladium‐ and photoredox‐catalyzed CH olefination enables the synthesis of indoles. By using visible light, the direct CH activation of aromatic enamines can be achieved and a variety of indole derivatives can be obtained in good yields under mild reaction conditions. Coupling without coinage metals: A combined palladium‐ and photoredox‐catalyzed CH olefination serves to synthesize indoles. Using visible light, direct CH activation of aromatic enamines leads to a variety of indole derivatives in good yields under mild reaction conditions.
Bibliography:istex:54F1F976BB3117922535DB17184989C0F060D681
ark:/67375/WNG-J2LRFHG4-K
ArticleID:ANIE201405478
The research leading to these results was supported by the European Research Council under the European Union's Seventh Framework Programme (FP/2007-2013)/ERC Grant Agreement no. 617044 (SunCatChem).
European Union - No. 617044
The research leading to these results was supported by the European Research Council under the European Union’s Seventh Framework Programme (FP/2007‐2013)/ERC Grant Agreement no. 617044 (SunCatChem).
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201405478