The effects of gratitude expression on neural activity

• Published in: NeuroImage (Orlando, Fla.) Vol. 128; pp. 1 - 10
• Main Authors: Kini, Prathik, Wong, Joel, McInnis, Sydney, Gabana, Nicole, Brown, Joshua W.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2016; Elsevier Limited
• Subjects: Adolescent; Adult; Brain; Brain - physiology; Cognition & reasoning; Counseling; Cross-Sectional Studies; Decision making; Emotions - physiology; Empathy; Female; fmri; Gratitude; Humans; Interpersonal Relations; Intervention; Magnetic Resonance Imaging; Male; Mental depression; Mental health; NMR; Nuclear magnetic resonance; Plasticity; Young Adult; Gratitude; Empathy; fmri; Plasticity; Counseling
• ISSN: 1053-8119; 1095-9572; 1095-9572
• DOI: 10.1016/j.neuroimage.2015.12.040

Gratitude is a common aspect of social interaction, yet relatively little is known about the neural bases of gratitude expression, nor how gratitude expression may lead to longer-term effects on brain activity. To address these twin issues, we recruited subjects who coincidentally were entering psychotherapy for depression and/or anxiety. One group participated in a gratitude writing intervention, which required them to write letters expressing gratitude. The therapy-as-usual control group did not perform a writing intervention. After three months, subjects performed a “Pay It Forward” task in the fMRI scanner. In the task, subjects were repeatedly endowed with a monetary gift and then asked to pass it on to a charitable cause to the extent they felt grateful for the gift. Operationalizing gratitude as monetary gifts allowed us to engage the subjects and quantify the gratitude expression for subsequent analyses. We measured brain activity and found regions where activity correlated with self-reported gratitude experience during the task, even including related constructs such as guilt motivation and desire to help as statistical controls. These were mostly distinct from brain regions activated by empathy or theory of mind. Also, our between groups cross-sectional study found that a simple gratitude writing intervention was associated with significantly greater and lasting neural sensitivity to gratitude – subjects who participated in gratitude letter writing showed both behavioral increases in gratitude and significantly greater neural modulation by gratitude in the medial prefrontal cortex three months later. •Subjects performed a “Pay It Forward” gratitude task with fMRI.•BOLD signal correlates of gratitude expression found in cognitive regions.•A brief gratitude writing intervention increased BOLD gratitude sensitivity.•The BOLD effects of writing intervention persisted three months later.