Left ventricular torsion shear angle volume analysis in patients with hypertension: a global approach for LV diastolic function

• Published in: Journal of cardiovascular magnetic resonance Vol. 16; no. 1; p. 70
• Main Authors: Schiros, Chun G, Desai, Ravi V, Venkatesh, Bharath Ambale, Gaddam, Krishna K, Agarwal, Shilpi, Lloyd, Steven G, Calhoun, David A, Denney, Jr, Thomas S, Dell'italia, Louis J, Gupta, Himanshu
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 26.09.2014; BioMed Central
• Subjects: Adult; Aged; Analysis; Biomechanical Phenomena; Cardiology; Care and treatment; Case-Control Studies; Colleges & universities; Diagnosis; Diastole; Female; Heart failure; Humans; Hypertension; Hypertension - complications; Hysteresis; Magnetic resonance; Magnetic Resonance Imaging, Cine; Male; Measurement; Middle Aged; Patients; Physiological aspects; Predictive Value of Tests; Prospective Studies; Remodeling; Shear; Suctioning; Torsion; Torsion, Mechanical; Ventricular Dysfunction, Left - diagnosis; Ventricular Dysfunction, Left - etiology; Ventricular Dysfunction, Left - physiopathology; Ventricular Function, Left; Ventricular Remodeling
• ISSN: 1097-6647; 1532-429X; 1532-429X
• DOI: 10.1186/s12968-014-0070-4

Torsion shear angle φ is an important measure of left ventricular (LV) systolic and diastolic functions. Here we provide a novel index utilizing LV normalized torsion shear angle φ ^ volume V ^ loop to assess LV diastolic functional properties. We defined the area within φ ^ V ^ loop as torsion hysteresis area, and hypothesized that it may be an important global parameter of diastolic function. We evaluated the φ ^ changes to increased V ^ during early diastole - d φ ^ / d V ^ as a potential measure of LV suction. Sixty resistant hypertension patients (HTN), forty control volunteers were studied using cardiovascular magnetic resonance with tissue tagging. Volumetric and torsional parameters were evaluated. HTN demonstrated concentric remodeling with preserved ejection fraction. HTN had significantly decreased normalized early filling rate, early diastolic mitral annulus velocity and E/A (1.33 ± 1.13 vs. 2.19 ± 1.07, P < 0.0001) vs. control. Torsion hysteresis area was greater (0.11 ± 0.07 vs. 0.079 ± 0.045, P < 0.001) and peak - d φ ^ / d V ^ at early diastole was higher (10.46 ± 8.51 vs. 6.29 ± 3.85, P = 0.002) than control. Torsion hysteresis area was significantly correlated with E/A (r = -0.23, P = 0.025). Thirteen HTN patients had both E/A ratio < 1.12 (Control mean E/A-1SD) and torsion hysteresis area > 0.12 (Control mean torsion hysteresis area + 1SD). Torsion hysteresis area and peak early diastolic - d φ ^ / d V ^ were significantly increased in hypertensive concentric remodeling. The φ ^ V ^ loop takes into account the active and passive recoil processes of LV diastolic and systolic phases, therefore provides a new global description of LV diastolic function.