Antiproliferative polyketides from fungus Xylaria cf. Longipes SWUF08-81 in different culture media

Bioactive compounds from the wood-decay fungus Xylaria cf. longipes SWUF08-81, cultivated in three different culture media (GM, YM and PDB), were isolated. Their structures and stereochemistry were deduced from spectroscopic and MS data analysis, together with quantum chemical calculations of 13 C N...

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Published inNatural products and bioprospecting Vol. 14; no. 1; p. 6
Main Authors Sresuksai, Kittiwan, Sawadsitang, Sasiphimol, Jantaharn, Phongphan, Noppawan, Pakin, Churat, Audomsak, Suwannasai, Nuttika, Mongkolthanaruk, Wiyada, Senawong, Thanaset, Tontapha, Sarawut, Moontragoon, Pairot, Amornkitbamrung, Vittaya, McCloskey, Sirirath
Format Journal Article
LanguageEnglish
Published Singapore Springer Nature Singapore 01.12.2024
Springer Nature B.V
SpringerOpen
Subjects
Antiproliferative activity
Asperentin
Bioactive compounds
Biocompatibility
Biological activity
Biomedical and Life Sciences
Bioorganic Chemistry
Carbon
Cell culture
Circular dichroism
Culture media
Cytotoxicity
Data analysis
Decay fungi
Dibenzofuran
Dichroism
Food Science
Fungi
HPLC analysis
Life Sciences
Medicinal Chemistry
Natural products
NMR
Nuclear magnetic resonance
Original Article
Pharmacology/Toxicology
Plant Biochemistry
Plant Sciences
Polyketides
Pyran
Quantum chemistry
Stereochemistry
Tumor cell lines
Xylaria
Antiproliferative activity
HPLC analysis
Asperentin
Pyran
Dibenzofuran
Xylaria
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Summary:Bioactive compounds from the wood-decay fungus Xylaria cf. longipes SWUF08-81, cultivated in three different culture media (GM, YM and PDB), were isolated. Their structures and stereochemistry were deduced from spectroscopic and MS data analysis, together with quantum chemical calculations of 13 C NMR chemical shifts and electronic circular dichroism (ECD) spectra. Five undescribed polyketides including dibenzofuran ( 1 ), mellein ( 2 ), dihydroisocoumarin ( 15 ), and two pyrans ( 16 , 17 ), together with twenty-three compounds were determined. Compounds 18 and 20 were significantly toxic against cancer cell lines (HCT116, HT29, MCF-7 and HeLa) based on the MTT assay. Quantification by HPLC showed that 18 was produced three-fold higher in the broth of PDB than YM. These studies showed that the production of different compounds were primarily dependent on nutrition sources and it has given a starting point for the growth optimization conditions for the scaling up of bioactive compounds production. Graphical Abstract
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ISSN:2192-2195
2192-2209
DOI:10.1007/s13659-023-00427-7