Identification of Another Member of the Transforming Growth Factor Type β Gene Family

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 85; no. 13; pp. 4715 - 4719
• Main Authors: Dijke, Peter Ten, Hansen, Pamela, Iwata, Kenneth K., Pieler, Christian, Foulkes, J. Gordon
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences of the United States of America 01.07.1988; National Acad Sciences
• Subjects: Amino Acid Sequence; Amino acids; Base Sequence; Cell lines; Complementary DNA; DNA; DNA - genetics; DNA, Neoplasm - genetics; Growth inhibitors; Humans; Messenger RNA; Molecular Sequence Data; Multigene Family; Neoplasm Proteins - genetics; Peptides - genetics; Proteins; Rhabdomyosarcoma - genetics; Rhabdomyosarcoma - pathology; RNA; Sequence Homology, Nucleic Acid; Terminology; Transforming Growth Factors; Tumor Cells, Cultured; Umbilical cord
• ISSN: 0027-8424; 1091-6490
• DOI: 10.1073/pnas.85.13.4715

We report here the complete amino acid sequence of another member of the type β transforming growth factor gene family, deduced from the nucleotide sequence of three overlapping cDNA clones. The C-terminal 112 amino acids share ≈ 80% sequence identity with type β 1 and β 2 transforming growth factors, with many of the remaining differences being conservative substitutions. By analogy to type β 1 and type β 2 transforming growth factors, we predict the protein to be synthesized as a 412 amino acid precursor that undergoes proteolytic cleavage to produce the mature polypeptide.