Assessment of thoracic spinal cord electrophysiological activity through magnetoneurography

• Published in: Clinical neurophysiology Vol. 133; pp. 39 - 47
• Main Authors: Hashimoto, Jun, Kawabata, Shigenori, Sasaki, Toru, Hoshino, Yuko, Sekihara, Kensuke, Adachi, Yoshiaki, Watanabe, Taishi, Miyano, Yuki, Mitani, Yuki, Sato, Shinji, Kim, Sukchan, Yoshii, Toshitaka, Okawa, Atsushi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2022
• Subjects: Adult; Electric Stimulation; Electrophysiological activity; Healthy Volunteers; Humans; Magnetic Fields; Magnetoneurography; Magnetospinography; Male; Middle Aged; Neural Conduction - physiology; Sciatic nerve stimulation; Spinal cord; Spinal Cord - physiology; Thoracic myelopathy; Thoracic Vertebrae; Spinal cord; Magnetospinography; OPLL; MRI; SQUID; MNG; Thoracic myelopathy; Magnetoneurography; SNR; Sciatic nerve stimulation; SCEP; Electrophysiological activity; SEP
• ISSN: 1388-2457; 1872-8952
• DOI: 10.1016/j.clinph.2021.09.023

•The biomagnetic field around the current flowing in the thoracic spinal cord was measured by a magnetoneurograph system.•Our novel method for synchronized bilateral sciatic nerve stimulation obtained an adequate magnetic signal for assessment.•This is the first report to achieve noninvasive and detailed visualization of thoracic electrophysiological activity. Noninvasive and detailed visualization of electrophysiological activity in the thoracic spinal cord through magnetoneurography. In five healthy volunteers, magnetic fields around current flowing in the thoracic spinal cord after alternating unilateral and synchronized bilateral sciatic nerve stimulation were measured using a magnetoneurograph system with superconductive quantum interference device biomagnetometers. The current distribution was obtained from the magnetic data by spatial filtering and visualized by superimposing it on the X-ray image. Conduction velocity was calculated using the peak latency of the current waveforms. A sufficiently high magnetic signal intensity and signal-to-noise ratio were obtained in all participants after synchronized bilateral sciatic nerve stimulation. Leading and trailing components along the spinal canal and inward components flowing into the depolarization site ascended to the upper thoracic spine. Conduction velocity of the inward current in the whole thoracic spine was 42.4 m/s. Visualization of electrophysiological activity in the thoracic spinal cord was achieved through magnetoneurography and a new method for synchronized bilateral sciatic nerve stimulation. Magnetoneurography is expected to be a useful modality in functional assessment of thoracic myelopathy. This is the first report to use magnetoneurography to noninvasively visualize electrophysiological activity in the thoracic spinal cord in detail.