The Use of Wearable Pulse Oximeters in the Prompt Detection of Hypoxemia and During Movement: Diagnostic Accuracy Study

• Published in: Journal of medical Internet research Vol. 24; no. 2; p. e28890
• Main Authors: Santos, Mauro, Vollam, Sarah, Pimentel, Marco Af, Areia, Carlos, Young, Louise, Roman, Cristian, Ede, Jody, Piper, Philippa, King, Elizabeth, Harford, Mirae, Shah, Akshay, Gustafson, Owen, Tarassenko, Lionel, Watkinson, Peter
• Format: Journal Article
• Language: English
• Published: Canada Journal of Medical Internet Research 15.02.2022; Gunther Eysenbach MD MPH, Associate Professor; JMIR Publications
• Subjects: Accuracy; Bias; Clinical outcomes; COVID-19; Data collection; Deterioration; Electrocardiography; Ethics; Heart rate; Humans; Hypoxia; Hypoxia - diagnosis; Medical diagnosis; Motion; Original Paper; Oximetry; Oxygen; Oxygen saturation; Pulse oximetry; Reliability; Reproducibility of Results; Risk management; Sample size; SARS-CoV-2; Saturation; Software; Standardization; Task performance; Vital signs; Wearable computers; Wearable Electronic Devices; United Kingdom > UK; United States > US; China; continuous monitoring; hypoxemia; hypoxia; diagnostic accuracy; deterioration; mHealth; wearable pulse oximeter; wearable technology; hospital; blood oxygen; patient monitoring
• ISSN: 1438-8871; 1439-4456; 1438-8871
• DOI: 10.2196/28890

Commercially available wearable (ambulatory) pulse oximeters have been recommended as a method for managing patients at risk of physiological deterioration, such as active patients with COVID-19 disease receiving care in hospital isolation rooms; however, their reliability in usual hospital settings is not known. We report the performance of wearable pulse oximeters in a simulated clinical setting when challenged by motion and low levels of arterial blood oxygen saturation (SaO ). The performance of 1 wrist-worn (Wavelet) and 3 finger-worn (CheckMe O2+, AP-20, and WristOx2 3150) wearable, wireless transmission-mode pulse oximeters was evaluated. For this, 7 motion tasks were performed: at rest, sit-to-stand, tapping, rubbing, drinking, turning pages, and using a tablet. Hypoxia exposure followed, in which inspired gases were adjusted to achieve decreasing SaO levels at 100%, 95%, 90%, 87%, 85%, 83%, and 80%. Peripheral oxygen saturation (SpO ) estimates were compared with simultaneous SaO samples to calculate the root-mean-square error (RMSE). The area under the receiver operating characteristic curve was used to analyze the detection of hypoxemia (ie, SaO <90%). SpO estimates matching 215 SaO samples in both study phases, from 33 participants, were analyzed. Tapping, rubbing, turning pages, and using a tablet degraded SpO estimation (RMSE>4% for at least 1 device). All finger-worn pulse oximeters detected hypoxemia, with an overall sensitivity of ≥0.87 and specificity of ≥0.80, comparable to that of the Philips MX450 pulse oximeter. The SpO accuracy of wearable finger-worn pulse oximeters was within that required by the International Organization for Standardization guidelines. Performance was degraded by motion, but all pulse oximeters could detect hypoxemia. Our findings support the use of wearable, wireless transmission-mode pulse oximeters to detect the onset of clinical deterioration in hospital settings. ISRCTN Registry 61535692; http://www.isrctn.com/ISRCTN61535692. RR2-10.1136/bmjopen-2019-034404.