Endocrine disrupting effects of 4-nonylphenol on plasma vitellogenin, reproductive system and histology in koi carp (Cyprinus carpio)

• Published in: International aquatic research Vol. 10; no. 3; pp. 263 - 274
• Main Authors: Amaninejad, Parisa, Hosseinzadeh Sahafi, Homayoun, Soltani, Mehdi, Hosseini Shekarabi, Seyed Pezhman
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2018; Springer; Islamic Azad University, Tonekabon Branch, Vali abad; Islamic Azad University
• Subjects: 17β-Estradiol; Alkylphenols; Aquatic Pollution; Body weight; Carp; Chemical pollutants; Chemical pollution; Coconut oil; Control; Cyprinus carpio; Disruption; Earth and Environmental Science; Ecotoxicology; Endocrine disruptors; Environment; Ethanol; Fish; Fishery research; Freshwater & Marine Ecology; Freshwater fishes; Fuel consumption; Hepatotoxicity; Histology; Histopathology; Koi; Koi carp; Liver; Marine & Freshwater Sciences; Nonylphenol; Organic chemistry; Original Research; Ovaries; Parameters; Physiological aspects; Pollutants; Progesterone; Reproductive system; Sex hormones; Testosterone; Toxicity; Vitellogenin; Waste Water Technology; Water; Water Management; Water Pollution Control; Xenoestrogens; Histopathology; Nonylphenol; Reproductive system; Vitellogenin; Koi carp
• ISSN: 2008-4935; 2008-6970
• DOI: 10.1007/s40071-018-0203-8

This study aimed to assess the effect of 4-nonylphenol (4-NP), a ubiquitous aquatic micro-chemical pollutant substance on some on some reproductive parameters and histology in koi carp. Fish were intraperitoneally subjected to ascending doses of 4-NP at 10, 50 and 100 μg/g body weight (BW) on days 7, 14 and 21 after the initiation of the experiment. Also, one group was treated with 17β-estradiol (E2) at 2 μg/g BW, positive control group (C2) received the vehicle (50 μL of coconut oil + 50 μL Ethanol) per fish and a negative control group (C1) was considered without injection. The results showed that 4-NP induced significantly an increase in E2, progesterone, and plasma vitellogenin at 50 μg/g in both male and female, while level of testosterone significantly decreased in the treated fish compared to control fish ( P  < 0.05). Conversely, the levels of these parameters at the higher concentration of 4-NP (100 μg/g) were significantly reduced compared to control one ( P  < 0.05). Also, some sever histopathological changes were observed in ovary, testicular and liver of treated fish, reflecting fish sensitivity to 4-NP at higher doses. This study showed that 4-NP has an estrogenic potency in the sexual development, hepatotoxicity and gonado-toxicity of koi carp.