Stretchy Proteins on Stretchy Substrates: The Important Elements of Integrin-Mediated Rigidity Sensing

Matrix and tissue rigidity guides many cellular processes, including the differentiation of stem cells and the migration of cells in health and disease. Cells actively and transiently test rigidity using mechanisms limited by inherent physical parameters that include the strength of extracellular at...

Full description

Saved in:
Bibliographic Details
Published inDevelopmental cell Vol. 19; no. 2; pp. 194 - 206
Main Authors Moore, Simon W., Roca-Cusachs, Pere, Sheetz, Michael P.
Format Journal Article
LanguageEnglish
Published Cambridge, MA Elsevier Inc 17.08.2010
Cell Press
Subjects
Animals
Biological and medical sciences
Cell Adhesion - physiology
Cell differentiation, maturation, development, hematopoiesis
Cell physiology
Elasticity
Extracellular Matrix - chemistry
Extracellular Matrix - metabolism
Fundamental and applied biological sciences. Psychology
Integrins - chemistry
Integrins - metabolism
Mechanoreceptors - chemistry
Mechanoreceptors - metabolism
Mechanotransduction, Cellular - physiology
Models, Biological
Molecular and cellular biology
Development
Protein
Integrin
Online AccessGet full text

Cover

More Information
Summary:Matrix and tissue rigidity guides many cellular processes, including the differentiation of stem cells and the migration of cells in health and disease. Cells actively and transiently test rigidity using mechanisms limited by inherent physical parameters that include the strength of extracellular attachments, the pulling capacity on these attachments, and the sensitivity of the mechanotransduction system. Here, we focus on rigidity sensing mediated through the integrin family of extracellular matrix receptors and linked proteins and discuss the evidence supporting these proteins as mechanosensors.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1534-5807
1878-1551
DOI:10.1016/j.devcel.2010.07.018