Advanced optoacoustic methods for multiscale imaging of in vivo dynamics
Visualization of dynamic functional and molecular events in an unperturbed in vivo environment is essential for understanding the complex biology of living organisms and of disease state and progression. To this end, optoacoustic (photoacoustic) sensing and imaging have demonstrated the exclusive ca...
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| Published in | Chemical Society reviews Vol. 46; no. 8; pp. 2158 - 2198 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
18.04.2017
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Visualization of dynamic functional and molecular events in an unperturbed
in vivo
environment is essential for understanding the complex biology of living organisms and of disease state and progression. To this end, optoacoustic (photoacoustic) sensing and imaging have demonstrated the exclusive capacity to maintain excellent optical contrast and high resolution in deep-tissue observations, far beyond the penetration limits of modern microscopy. Yet, the time domain is paramount for the observation and study of complex biological interactions that may be invisible in single snapshots of living systems. This review focuses on the recent advances in optoacoustic imaging assisted by smart molecular labeling and dynamic contrast enhancement approaches that enable new types of multiscale dynamic observations not attainable with other bio-imaging modalities. A wealth of investigated new research topics and clinical applications is further discussed, including imaging of large-scale brain activity patterns, volumetric visualization of moving organs and contrast agent kinetics, molecular imaging using targeted and genetically expressed labels, as well as three-dimensional handheld diagnostics of human subjects.
Multiscale optoacoustic imaging - from single cells to whole organisms, from sub-millisecond biological dynamics to longitudinal studies with unprecedented image quality. |
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| Bibliography: | Shy Shoham is Professor of Biomedical Engineering at the Technion - Israel Institute of Technology, and a Visiting Professor of Neuroscience at NYU Langone Medical Center. He heads the Technion's Neural Interface Engineering Lab (NIEL), which develops and applies photonic, acoustic and computational tools for spatiotemporal interfacing with neural circuits. Prof. Shoham holds a BSc in Physics from Tel Aviv University, a PhD in Bioengineering from the University of Utah, and was a Lewis-Thomas postdoctoral fellow at Princeton University. He is a member of the editorial boards of the Journal of Neural Engineering and of Translational Vision Science & Technology. Daniel Razansky is Professor of Molecular Imaging Engineering at the Technical University of Munich and Helmholtz Center Munich. He earned degrees in Electrical and Biomedical Engineering from the Technion - Israel Institute of Technology and completed postdoctoral training at the Harvard Medical School. Prof. Razansky published over 150 journal articles and holds 12 inventions in the bio-imaging discipline. His Lab pioneered a number of new imaging techniques that have been successfully commercialized worldwide, among them the multi-spectral optoacoustic tomography (MSOT). He also serves on the editorial boards of journals published by the Nature Publishing Group, Elsevier, IEEE and AAPM. Xosé Luís Deán Ben received the diploma in automatics and electronics engineering from the Universidade de Vigo in 2004. He received the PhD degree from the same university in 2009. In 2010 he joined the Multiscale Functional and Molecular Imaging Group at the Institute for Biological and Medical Imaging (IBMI), Helmholtz Center Munich. His major research interests are the development of new optoacoustic systems for preclinical and clinical applications and the elaboration of mathematical algorithms for fast and accurate imaging performance. Sven Gottschalk holds a diploma in chemistry and a PhD degree from the University of Bremen, Germany. After researching on contrast agent development for magnetic resonance imaging at the Max Planck Institute for Biological Cybernetics in Tübingen, Germany, he joined the Institute for Biological and Medical Imaging (IBMI) in Munich. At IBMI, his research focus is on the development of biomedical applications of state-of-the-art multi-spectral optoacoustic tomography and microscopy systems. He is currently interested in functional optoacoustic neuroimaging and the application of novel imaging probes and contrast agents for optoacoustic imaging. Ben Mc Larney is currently a PhD Student under the supervision of Prof. D. Razansky at the Faculty of Medicine, Technical University of Munich, Germany. Ben received a BSc in Cellular and Molecular Biology from the University College Dublin, Ireland and an MSc in Microscopy and Imaging from the same University in 2015. His major research interests are developing new methods to image large scale neuronal communication using optoacoustics, cell engineering and 3D printing. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| ISSN: | 0306-0012 1460-4744 1460-4744 |
| DOI: | 10.1039/c6cs00765a |