Multiplexed RNA trafficking in oligodendrocytes and neurons

In oligodendrocytes and neurons genetic information is transmitted from the nucleus to dendrites in the form of RNA granules. Here we describe how transport of multiple different RNA molecules in individual granules is analogous to the process of multiplexing in telecommunications. In both cases mul...

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Published inBiochimica et biophysica acta Vol. 1779; no. 8; pp. 453 - 458
Main Authors Carson, John H., Gao, Yuanzheng, Tatavarty, Vedakumar, Levin, Mikhail K., Korza, George, Francone, Victor P., Kosturko, Linda D., Maggipinto, Michael J., Barbarese, Elisa
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.08.2008
Subjects
Animals
Cell Nucleus - metabolism
Dendrites - metabolism
HnRNP A2
Humans
Myelin
Neurons - metabolism
Oligodendroglia - metabolism
RNA - metabolism
RNA granule
RNA Transport - physiology
Synapse
TOG
Synapse
HnRNP A2
Myelin
TOG
RNA granule
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Summary:In oligodendrocytes and neurons genetic information is transmitted from the nucleus to dendrites in the form of RNA granules. Here we describe how transport of multiple different RNA molecules in individual granules is analogous to the process of multiplexing in telecommunications. In both cases multiple messages are combined into a composite signal for transmission on a single carrier. Multiplexing provides a mechanism to coordinate local expression of ensembles of genes in myelin in oligodendrocytes and at synapses in neurons.
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ISSN:1874-9399
0006-3002
1876-4320
DOI:10.1016/j.bbagrm.2008.04.002