Increased expression of cytokines, soluble cytokine receptors, soluble apoptosis ligand and apoptosis in dengue

Abstract Several studies have been performed to determine biomarkers that define the risk factors to developing severe forms of dengue. In this study, the levels of TNF-α, IL-6, IL-1, IL-17, soluble interleukin-1 receptor like 1 protein (sST2), soluble TNF-related apoptosis-inducing ligand (sTRAIL),...

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Published inVirology (New York, N.Y.) Vol. 452; pp. 42 - 51
Main Authors Arias, Julia, Valero, Nereida, Mosquera, Jesús, Montiel, Milagros, Reyes, Eduardo, Larreal, Yraima, Alvarez-Mon, Melchor
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.03.2014
Subjects
Adolescent
Adult
Apoptosis
Child
Child, Preschool
Cytokines
Cytokines - genetics
Cytokines - immunology
Dengue
Dengue - genetics
Dengue - immunology
Dengue - physiopathology
Dengue - virology
Dengue Virus - classification
Dengue Virus - genetics
Dengue Virus - physiology
Disease severity
Female
Humans
Infant
Infectious Disease
Male
Monocytes
Receptors, Cytokine - genetics
Receptors, Cytokine - immunology
TNF-Related Apoptosis-Inducing Ligand - genetics
TNF-Related Apoptosis-Inducing Ligand - immunology
Up-Regulation
Young Adult
Disease severity
Monocytes
Cytokines
Dengue
Apoptosis
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Summary:Abstract Several studies have been performed to determine biomarkers that define the risk factors to developing severe forms of dengue. In this study, the levels of TNF-α, IL-6, IL-1, IL-17, soluble interleukin-1 receptor like 1 protein (sST2), soluble TNF-related apoptosis-inducing ligand (sTRAIL), IL-12 and soluble receptors for TNF (sTNF-RI and sTNF-RII) were determined by ELISA in dengue patients and monocyte/macrophage cultures. Dengue was classified as dengue without warning symptoms (DNWS), with warning symptoms (DWWS) and severe dengue (SD). High values of IL-6, sTNFRI, sTNFRII and sST2 were observed in DWWS and/or SD and IL-12 and sTRAIL in DNWS. TNF-α and IL-17 were increased not associated to the disease severity. High production of TNF-α, IL-1β, IL-12, IL-17, sST2 and sTRAIL and apoptosis expression were observed in dengue monocyte/macrophage cultures. This study shows that beneficial or deleterious biomarkers can be present in dengue regardless the disease severity and that monocytes may be in part the source of studied molecules.
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ISSN:0042-6822
1096-0341
DOI:10.1016/j.virol.2013.12.027