Primary Thyroid Lymphoma: A Retrospective-Observational Study in a Single Institutional Center

• Published in: Medicina (Kaunas, Lithuania) Vol. 60; no. 3; p. 476
• Main Authors: Vita, Octavia, Dema, Alis, Barna, Robert, Cornea, Remus, Brebu, Dan, Vlad, Mihaela, Popa, Oana, Muntean, Ioana, Szilagyi, Diana, Iacob, Mihaela, Iordache, Maria, Cornianu, Marioara, Lazureanu, Dorela Codruta
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.03.2024; MDPI
• Subjects: Age; Aged; Aged, 80 and over; Analysis; B cells; Biopsy; Cervical cancer; Chemotherapy; Classification; Female; fine needle aspirate; Hashimoto Disease - complications; Hashimoto Disease - diagnosis; Hashimoto Disease - pathology; Hashimoto thyroiditis; Health aspects; Humans; Lymphatic system; Lymphoma; Lymphoma, Large B-Cell, Diffuse - diagnosis; Male; Medical prognosis; Middle Aged; non-Hodgkin B-cell lymphomas; Non-Hodgkin's lymphomas; Patient compliance; Patients; primary thyroid lymphoma; Radiation therapy; Retrospective Studies; survival; Thoracic surgery; Thyroid diseases; Thyroid gland; Thyroid Neoplasms; Thyroidectomy; Tumors; Vincristine; Romania; primary thyroid lymphoma; Hashimoto thyroiditis; fine needle aspirate; non-Hodgkin B-cell lymphomas; survival
• ISSN: 1648-9144; 1010-660X; 1648-9144
• DOI: 10.3390/medicina60030476

: primary thyroid lymphoma (PTL) is a rare neoplasm, displaying a variety of histological features. It is often a challenge for pathologists to diagnose this tumor. : this study is a retrospective analysis of clinical and pathological characteristics of a group of eleven patients (eight women and three men, mean age 68 years, range 50-80 years) diagnosed with PTL. : nine patients (81.81%) presented a tumor with progressive growth in the anterior cervical region, usually painless and accompanied by local compressive signs. Histologically, we identified six cases (55%) of diffuse large B-cell lymphoma, three cases (27%) of extranodal marginal zone lymphoma, one case (9%) of follicular lymphoma, and one case (9%) of mixed follicular-diffuse lymphoma. PTL was associated with microscopic Hashimoto autoimmune thyroiditis in ten cases (90.9%). Ten patients (90.9%) presented with localized disease (stage I-IIE). A percentage of 60% of patients survived over 5 years. We observed an overall longer survival in patients under 70 years of age. : PTL represents a diagnosis that needs to be taken into account, especially in women with a history of Hashimoto autoimmune thyroiditis, presenting a cervical tumor with progressive growth. PTL is a lymphoid neoplasia with favorable outcome, with relatively long survival if it is diagnosed at younger ages.