Systemic Juvenile Idiopathic Arthritis and Secondary Macrophage Activation Syndrome in Latvia from 2009 to 2020: A Nationwide Retrospective Study

• Published in: Medicina (Kaunas, Lithuania) Vol. 59; no. 4; p. 798
• Main Authors: Lukjanoviča, Kristīne, Šlēziņa, Ieva, Dāvidsone, Zane, Šantere, Ruta, Budarina, Kristīna, Staņēviča, Valda
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.04.2023; MDPI
• Subjects: Analysis; Arthritis; Arthritis, Juvenile - complications; Arthritis, Juvenile - drug therapy; Arthritis, Juvenile - epidemiology; Bone marrow; Care and treatment; Child; Chronic illnesses; Classification; Diagnosis; Disease; Fever; Fever - complications; Hospitals; Humans; Infections; Juvenile arthritis; Laboratories; Latvia - epidemiology; macrophage activation syndrome; Macrophage Activation Syndrome - complications; Macrophage Activation Syndrome - diagnosis; Macrophage Activation Syndrome - epidemiology; Macrophages; MAS; Pathogenesis; Patients; Pediatrics; Retrospective Studies; Rheumatology; sJIA; Steroids; still’s disease; systemic juvenile idiopathic arthritis; Latvia; still’s disease; systemic juvenile idiopathic arthritis; juvenile arthritis; tocilizumab; macrophage activation syndrome; sJIA; MAS
• ISSN: 1648-9144; 1010-660X; 1648-9144
• DOI: 10.3390/medicina59040798

: Systemic juvenile idiopathic arthritis (sJIA) is a distinctive JIA subtype with mostly nonspecific systemic clinical features, which can be a diagnostic challenge. This study aimed to analyze our experience with sJIA in Latvia for twelve years: assessing clinical and epidemiological characteristics, the efficacy of therapy, and disease outcomes, including the development of macrophage activation syndrome (MAS). : This is a descriptive study in which we conducted a retrospective case review of all patients with sJIA diagnosis admitted to the only pediatric tertiary centre in Latvia during the period 2009-2020. sJIA was diagnosed in 35 patients with a mean annual incidence rate of 0.85 patients per 100,000 children. Major clinical signs at the first visit were: fever, rash, arthritis, and lymphadenopathy. Almost half of the patients, 48.5%, had a monocyclic disease course, and only 20% of patients had persistent disease. MAS developed in 28.6% of patients. Biological therapy was administered to 48.6% of patients, mostly by tocilizumab, which induced remission in 75% after one year, and in 81.2% after two years without any serious therapy-related complications. In our study, none of the patients had interstitial lung disease, drug reaction with eosinophilia and systemic symptoms (DRESS)-like syndrome, or fatal disease. The incidence and clinical characteristics of sJIA correlate with the literature findings, although MAS was more common than described in other studies. There is a tendency for the persistent disease to decrease with the use of biological therapy. Tocilizumab is an efficient choice of treatment with a good safety profile.