Abnormal intrinsic and extrinsic connectivity within the magnetic mismatch negativity brain network in schizophrenia: A preliminary study

• Published in: Schizophrenia research Vol. 135; no. 1; pp. 23 - 27
• Main Authors: Dima, D, Frangou, S, Burge, L, Braeutigam, S, James, A.C
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.03.2012; Elsevier
• Subjects: Acoustic Stimulation - methods; Adolescent; Adult and adolescent clinical studies; Auditory Pathways - physiopathology; Biological and medical sciences; Brain - physiopathology; Brain Mapping; Connectivity; Contingent Negative Variation - physiology; Dynamic causal modelling; Dysconnection syndrome; Electroencephalography; Error prediction; Evoked Potentials, Auditory - physiology; Experience dependent modulation; Female; Humans; Male; Medical sciences; Mismatch negativity; Models, Biological; Neuropsychological Tests; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Schizophrenia; Schizophrenia - pathology; Schizophrenia - physiopathology; Time Factors; Connectivity; Mismatch negativity; Dysconnection syndrome; Experience dependent modulation; Error prediction; Dynamic causal modelling; Human; Central nervous system; Stimulus disparity; Prediction; Electrophysiology; Schizophrenia; Cognition; Encephalon; Psychosis; Electrodiagnosis; Acoustic stimulus; Auditory evoked potential; Perception; Causality
• ISSN: 0920-9964; 1573-2509
• DOI: 10.1016/j.schres.2011.12.024

Abstract Altered neuroplasticity is increasingly invoked as a mechanism underpinning dysconnectivity in schizophrenia. We used Dynamic Causal Modelling to compare connectivity during the magnetic auditory Mismatch Negativity (MMN), an index of error prediction, between schizophrenia patients and controls. Patients showed reduced intrinsic connectivity within the primary auditory cortex suggestive of impaired local neuronal adaptation and disrupted forward and backward extrinsic connectivity throughout the MMN network indicative of reduced higher order input in disambiguating activity in lower network nodes. Our study provides the first empirical description of the dysplastic changes underpinning dysconnectivity between primary sensory and higher order cortical areas in schizophrenia.