A microwave-assisted bismuth nitrate-catalyzed unique route toward 1,4-dihydropyridines

The classical Hantzsch reaction is one of the simplest and most economical methods for the synthesis of biologically important and pharmacologically useful 1,4-dihydropyridine derivatives. Bismuth nitrate pentahydrate under microwave irradiation is proven to act as a very efficient catalyst for a on...

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Published inMolecules (Basel, Switzerland) Vol. 17; no. 3; pp. 2643 - 2662
Main Authors Bandyopadhyay, Debasish, Maldonado, Stephanie, Banik, Bimal K
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 05.03.2012
MDPI
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Summary:The classical Hantzsch reaction is one of the simplest and most economical methods for the synthesis of biologically important and pharmacologically useful 1,4-dihydropyridine derivatives. Bismuth nitrate pentahydrate under microwave irradiation is proven to act as a very efficient catalyst for a one-pot, three-component synthesis of 1,4-dihydropyridines in excellent yields from diverse amines/ammonium acetate, aldehydes and 1,3-dicarbonyl compounds within 1-3 min under solvent-free conditions. The present environmentally benign procedure for the synthesis of 1,4-dihydropyridines is suitable for library synthesis and it will find application in the synthesis of potent biologically active molecules. The excellent yield and extreme rapidity of the method is due to a concurrent effect of the catalyst and microwave irradiation.
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ISSN:1420-3049
1420-3049
DOI:10.3390/molecules17032643