The Hippo Signaling Pathway in Development and Cancer

First discovered in Drosophila, the Hippo signaling pathway is a conserved regulator of organ size. Central to this pathway is a kinase cascade leading from the tumor suppressor Hippo (Mst1 and Mst2 in mammals) to the oncoprotein Yki (YAP and TAZ in mammals), a transcriptional coactivator of target...

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Published in	Developmental cell Vol. 19; no. 4; pp. 491 - 505
Main Author	Pan, Duojia
Format	Journal Article
Language	English
Published	Cambridge, MA Elsevier Inc 19.10.2010 Cell Press
Subjects	Animals Biological and medical sciences Cell differentiation, maturation, development, hematopoiesis Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Drosophila melanogaster - metabolism Drosophila Proteins - metabolism Embryonic Development Fundamental and applied biological sciences. Psychology Gene Expression Regulation Humans Intracellular Signaling Peptides and Proteins - metabolism Molecular and cellular biology Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Protein Serine-Threonine Kinases - metabolism Signal Transduction Tumor Suppressor Proteins - metabolism Development Signal transduction Malignant tumor Cancer
Online Access	Get full text
ISSN	1534-5807 1878-1551 1878-1551
DOI	10.1016/j.devcel.2010.09.011

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Abstract	First discovered in Drosophila, the Hippo signaling pathway is a conserved regulator of organ size. Central to this pathway is a kinase cascade leading from the tumor suppressor Hippo (Mst1 and Mst2 in mammals) to the oncoprotein Yki (YAP and TAZ in mammals), a transcriptional coactivator of target genes involved in cell proliferation and survival. Here, I review recent progress in elucidating the molecular mechanism and physiological function of Hippo signaling in Drosophila and mammals. These studies suggest that the core Hippo kinase cascade integrates multiple upstream inputs, enabling dynamic regulation of tissue homeostasis in animal development and physiology.
AbstractList	First discovered in Drosophila, the Hippo signaling pathway is a conserved regulator of organ size. Central to this pathway is a kinase cascade leading from the tumor suppressor Hippo (Mst1 and Mst2 in mammals) to the oncoprotein Yki (YAP and TAZ in mammals), a transcriptional coactivator of target genes involved in cell proliferation and survival. Here, I review recent progress in elucidating the molecular mechanism and physiological function of Hippo signaling in Drosophila and mammals. These studies suggest that the core Hippo kinase cascade integrates multiple upstream inputs, enabling dynamic regulation of tissue homeostasis in animal development and physiology.First discovered in Drosophila, the Hippo signaling pathway is a conserved regulator of organ size. Central to this pathway is a kinase cascade leading from the tumor suppressor Hippo (Mst1 and Mst2 in mammals) to the oncoprotein Yki (YAP and TAZ in mammals), a transcriptional coactivator of target genes involved in cell proliferation and survival. Here, I review recent progress in elucidating the molecular mechanism and physiological function of Hippo signaling in Drosophila and mammals. These studies suggest that the core Hippo kinase cascade integrates multiple upstream inputs, enabling dynamic regulation of tissue homeostasis in animal development and physiology. First discovered in Drosophila , the Hippo signaling pathway is a conserved regulator of organ size. Central to this pathway is a kinase cascade leading from the tumor suppressor Hippo (Mst1 and Mst2 in mammals) to the oncoprotein Yki (YAP and TAZ in mammals), a transcriptional coactivator of target genes involved in cell proliferation and survival. Here, I review recent progress in elucidating the molecular mechanism and physiological function of Hippo signaling in Drosophila and mammals. These studies suggest that the core Hippo kinase cascade integrates multiple upstream inputs, enabling dynamic regulation of tissue homeostasis in animal development and physiology. First discovered in Drosophila, the Hippo signaling pathway is a conserved regulator of organ size. Central to this pathway is a kinase cascade leading from the tumor suppressor Hippo (Mst1 and Mst2 in mammals) to the oncoprotein Yki (YAP and TAZ in mammals), a transcriptional coactivator of target genes involved in cell proliferation and survival. Here, I review recent progress in elucidating the molecular mechanism and physiological function of Hippo signaling in Drosophila and mammals. These studies suggest that the core Hippo kinase cascade integrates multiple upstream inputs, enabling dynamic regulation of tissue homeostasis in animal development and physiology.
Author	Pan, Duojia
AuthorAffiliation	1 Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
AuthorAffiliation_xml	– name: 1 Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Author_xml	– sequence: 1 givenname: Duojia surname: Pan fullname: Pan, Duojia email: djpan@jhmi.edu organization: Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
BackLink	http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23341182$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/20951342$$D View this record in MEDLINE/PubMed
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Snippet	First discovered in Drosophila, the Hippo signaling pathway is a conserved regulator of organ size. Central to this pathway is a kinase cascade leading from... First discovered in Drosophila , the Hippo signaling pathway is a conserved regulator of organ size. Central to this pathway is a kinase cascade leading from...
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SubjectTerms	Animals Biological and medical sciences Cell differentiation, maturation, development, hematopoiesis Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Drosophila melanogaster - metabolism Drosophila Proteins - metabolism Embryonic Development Fundamental and applied biological sciences. Psychology Gene Expression Regulation Humans Intracellular Signaling Peptides and Proteins - metabolism Molecular and cellular biology Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Protein Serine-Threonine Kinases - metabolism Signal Transduction Tumor Suppressor Proteins - metabolism
Title	The Hippo Signaling Pathway in Development and Cancer
URI	https://dx.doi.org/10.1016/j.devcel.2010.09.011 https://www.ncbi.nlm.nih.gov/pubmed/20951342 https://www.proquest.com/docview/759132532 https://pubmed.ncbi.nlm.nih.gov/PMC3124840
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