The Hippo Signaling Pathway in Development and Cancer

• Published in: Developmental cell Vol. 19; no. 4; pp. 491 - 505
• Main Author: Pan, Duojia
• Format: Journal Article
• Language: English
• Published: Cambridge, MA Elsevier Inc 19.10.2010; Cell Press
• Subjects: Animals; Biological and medical sciences; Cell differentiation, maturation, development, hematopoiesis; Cell physiology; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes; Drosophila melanogaster - metabolism; Drosophila Proteins - metabolism; Embryonic Development; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation; Humans; Intracellular Signaling Peptides and Proteins - metabolism; Molecular and cellular biology; Neoplasms - genetics; Neoplasms - metabolism; Neoplasms - pathology; Protein Serine-Threonine Kinases - metabolism; Signal Transduction; Tumor Suppressor Proteins - metabolism; Development; Signal transduction; Malignant tumor; Cancer
• ISSN: 1534-5807; 1878-1551; 1878-1551
• DOI: 10.1016/j.devcel.2010.09.011

First discovered in Drosophila, the Hippo signaling pathway is a conserved regulator of organ size. Central to this pathway is a kinase cascade leading from the tumor suppressor Hippo (Mst1 and Mst2 in mammals) to the oncoprotein Yki (YAP and TAZ in mammals), a transcriptional coactivator of target genes involved in cell proliferation and survival. Here, I review recent progress in elucidating the molecular mechanism and physiological function of Hippo signaling in Drosophila and mammals. These studies suggest that the core Hippo kinase cascade integrates multiple upstream inputs, enabling dynamic regulation of tissue homeostasis in animal development and physiology.