Elastofibroma: a clinicopathologic and immunohistochemical study of seven cases and literature review
Elastofibroma is a rare fibrous lesion characterized by accumulated abnormal elastic fibers whose etiology remains largely unknown. In this study, we analyzed seven cases of elastofibroma to further explore the characteristics of its cellular composition. Immunohistochemistry was performed for mast...
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Published in | APMIS : acta pathologica, microbiologica et immunologica Scandinavica Vol. 115; no. 2; pp. 115 - 119 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Publishing Ltd
01.02.2007
Blackwell |
Subjects | |
Online Access | Get full text |
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Summary: | Elastofibroma is a rare fibrous lesion characterized by accumulated abnormal elastic fibers whose etiology remains largely unknown. In this study, we analyzed seven cases of elastofibroma to further explore the characteristics of its cellular composition. Immunohistochemistry was performed for mast cell tryptase, S‐100 protein, vimentin, CD34, smooth muscle actin, desmin and collagen type IV. Histochemical staining methods for Gomori's trichrome and Verhoeff elastica‐van Gieson were also evaluated. Histopathologically, a haphazard array of collagen, eosinophilic amorphous fibers, and globules in a fibrous tissue was seen. The elastic nature of the fibers was confirmed by elastic stain, and with Gomori's trichrome collagen fibers were also demonstrated. The interspersed spindle or stellate cells were almost consistently positive for vimentin and frequently positive for CD34. Mast cell tryptase‐positive cells were present in five of the cases. Collagen type IV immunoreactivity was seen in two cases. No staining was observed with smooth muscle actin, desmin or S‐100 protein. Our findings suggest that CD34‐positive mesenchymal cells are an integral component of elastofibroma. |
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Bibliography: | ArticleID:apm525 istex:5004CD1AE9104ADE548D875FA6723FE151493E0E ark:/67375/WNG-DZDVBGNX-D Received 7 June 2006. Accepted 28 August 2006. Accepted 28 August 2006. Received 7 June 2006. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0903-4641 1600-0463 |
DOI: | 10.1111/j.1600-0463.2007.apm_525.x |