Engineering Cell Membrane‐Cloaked Catalysts as Multifaceted Artificial Peroxisomes for Biomedical Applications

• Published in: Advanced science Vol. 10; no. 17; pp. e2206181 - n/a
• Main Authors: Yang, Dongmei, Tang, Yuanjiao, Zhu, Bihui, Pang, Houqing, Rong, Xiao, Gao, Yang, Du, Fangxue, Cheng, Chong, Qiu, Li, Ma, Lang
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.06.2023; John Wiley and Sons Inc; Wiley
• Subjects: Amino acids; Antioxidants; artificial peroxisome; Biocompatibility; Biocompatible Materials; biomedical application; Cancer; Catalysis; catalyst; Cell Membrane; Copyright; Enzymes; Glucose; Hyperglycemia; Hypoxia; Ischemia; Membranes; Metabolism; Nanomedicine; Nanoparticles; Oxidative stress; Peroxisomes - physiology; Polyethylene glycol; reactive oxygen species; Review; Reviews; Tumors; biomedical application; catalyst; artificial peroxisome; cell membrane; reactive oxygen species
• ISSN: 2198-3844; 2198-3844
• DOI: 10.1002/advs.202206181

Artificial peroxisomes (APEXs) or peroxisome mimics have caught a lot of attention in nanomedicine and biomaterial science in the last decade, which have great potential in clinically diagnosing and treating diseases. APEXs are typically constructed from a semipermeable membrane that encloses natural enzymes or enzyme‐mimetic catalysts to perform peroxisome‐/enzyme‐mimetic activities. The recent rapid progress regarding their biocatalytic stability, adjustable activity, and surface functionality has significantly promoted APEXs systems in real‐life applications. In addition, developing a facile and versatile system that can simulate multiple biocatalytic tasks is advantageous. Here, the recent advances in engineering cell membrane‐cloaked catalysts as multifaceted APEXs for diverse biomedical applications are highlighted and commented. First, various catalysts with single or multiple enzyme activities have been introduced as cores of APEXs. Subsequently, the extraction and function of cell membranes that are used as the shell are summarized. After that, the applications of these APEXs are discussed in detail, such as cancer therapy, antioxidant, anti‐inflammation, and neuron protection. Finally, the future perspectives and challenges of APEXs are proposed and outlined. This progress review is anticipated to provide new and unique insights into cell membrane‐cloaked catalysts and to offer significant new inspiration for designing future artificial organelles. Recent progress in engineering cell membrane‐cloaked catalysts as multifaceted artificial peroxisomes (APEXs) for diverse biomedical applications is summarized in this review. The reactive oxygen species‐based biomedical strategies to kill pathogenic cells or protect normal cells, such as cancer therapy, antioxidant, anti‐inflammation, neuron protection, and primary challenges and perspectives are carefully outlined, which will provide new horizons for further development of APEXs.