Transient receptor potential channel superfamily: Role in lower urinary tract function

• Published in: International journal of urology Vol. 22; no. 11; pp. 994 - 999
• Main Authors: Ogawa, Teruyuki, Imamura, Tetsuya, Nakazawa, Masaki, Hiragata, Shiro, Nagai, Takashi, Minagawa, Tomonori, Yokoyama, Hitoshi, Ishikawa, Masakuni, Domen, Takahisa, Ishizuka, Osamu
• Format: Journal Article
• Language: English
• Published: Australia Blackwell Publishing Ltd 01.11.2015
• Subjects: bladder; Humans; lower urinary tract; Lower Urinary Tract Symptoms - physiopathology; transient receptor potential; Transient Receptor Potential Channels - physiology; Urinary Bladder - physiopathology; Urinary Bladder, Neurogenic - physiopathology; Urinary Tract Physiological Phenomena; lower urinary tract; bladder; transient receptor potential
• ISSN: 0919-8172; 1442-2042
• DOI: 10.1111/iju.12861

Lower urinary tract symptoms associated with neurogenic bladder and overactive bladder syndrome are mediated in part by members of the transient receptor potential channel superfamily. The best studied member of this superfamily is the vanilloid receptor. Other transient receptor potential channels, such as the melastatin receptor and the ankyrin receptor, are also active in the pathogenesis of lower urinary tract dysfunction. However, the detailed mechanisms by which the transient receptor potential channels contribute to lower urinary tract symptoms are still not clear, and the therapeutic benefits of modulating transient receptor potential channel activity have not been proved in the clinical setting. In the present review, to better understand the pathophysiology and therapeutic potential for lower urinary tract symptoms, we summarize the presence and role of different members of the transient receptor potential channel superfamily in the lower urinary tract.