Histone regulator KAT2A acts as a potential biomarker related to tumor microenvironment and prognosis of diffuse large B cell lymphoma

Background Recent studies have indicated that epigenetic alterations contribute significantly to lymphoma pathogenesis. A type of epigenetic regulation known as histone acetylation plays a crucial role in transcriptional regulation in eukaryotic cells. Specifically, a significant effect of histone a...

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Published inBMC cancer Vol. 23; no. 1; pp. 1 - 934
Main Authors Yu, Zhuoya, Ding, Mengfei, Cai, Yiqing, Lu, Tiange, Chen, Xiaomin, Zhou, Xiangxiang, Wang, Xin
Format Journal Article
LanguageEnglish
Published London BioMed Central Ltd 03.10.2023
BioMed Central
BMC
Subjects
Acetylation
Analysis
Apoptosis
B-cell lymphoma
Biomarkers
Cancer
Cell cycle
Clustering
Development and progression
DLBCL
Epigenetic inheritance
Epigenetics
Gene expression
Gene regulation
Genes
Genetic aspects
Genomes
Health aspects
Histone acetylation
Histones
Immune status
Immune system
Immunotherapy
KAT2A
Lymphocytes B
Lymphoma
Medical prognosis
Metastases
Methylation
Mutation
Non-Hodgkin's lymphomas
Physiological aspects
Prognosis
Tumor markers
Tumor microenvironment
Tumors
China
United States > US
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Summary:Background Recent studies have indicated that epigenetic alterations contribute significantly to lymphoma pathogenesis. A type of epigenetic regulation known as histone acetylation plays a crucial role in transcriptional regulation in eukaryotic cells. Specifically, a significant effect of histone acetylation modifications on the abnormal progression and microenvironment of diffuse large B-cell lymphoma (DLBCL) has been observed. Methods To provide insight into the significance of histone acetylation-related genes, we developed a HAscore model for analyzing histone acetylation patterns in DLBCL samples. Furthermore, KAT2A, a regulator of histone acetylation, was knocked down in DLBCL cell lines to investigate its role in proliferation, cell cycle, and apoptosis. Results The HAscore model has been demonstrated to provide insight into the significance of these patterns, showing that patients with a low HAscore have distinct tumor immune microenvironments and poorer prognoses. Besides, KAT2A was identified as a potential biomarker related to immune infiltration and malignant pathways in DLBCL. Conclusion According to these findings, it is evident that the histone acetylation pattern score model is helpful in describing the immune status of DLBCL and that KAT2A may be used as a biomarker for its treatment. Keywords: DLBCL, Histone acetylation, Tumor microenvironment, KAT2A, Immunotherapy
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content type line 23
ISSN:1471-2407
1471-2407
DOI:10.1186/s12885-023-11401-4