Antisynthetase Syndrome Associated with Sarcoidosis

A 30-year-old man complained of polyarthralgia and fatigue. The clinical findings and laboratory data included myositis, polyarthritis, interstitial pneumonia, Raynaud's phenomenon, mechanic's hand, and anti PL-7 antibody (threonyl-tRNA synthetase antibody). All of these signs were consist...

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Bibliographic Details
Published inInternal Medicine Vol. 45; no. 18; pp. 1065 - 1068
Main Authors Asanuma, Yu, Koichihara, Reiko, Koyama, Shinichiro, Kawabata, Yoshinori, Kobayashi, Shio, Mimori, Tsuneyo, Moriguchi, Masato
Format Journal Article
LanguageEnglish
Published Japan The Japanese Society of Internal Medicine 01.01.2006
Subjects
Adult
antisynthetase syndrome
Autoantibodies - immunology
Autoimmune Diseases - complications
Autoimmune Diseases - drug therapy
Autoimmune Diseases - immunology
Glucocorticoids - therapeutic use
Humans
interstitial pneumonia
Ligases - immunology
Male
Prednisolone - therapeutic use
sarcoidosis
Sarcoidosis - complications
Sarcoidosis - drug therapy
Sarcoidosis - pathology
Smoking
Syndrome
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Summary:A 30-year-old man complained of polyarthralgia and fatigue. The clinical findings and laboratory data included myositis, polyarthritis, interstitial pneumonia, Raynaud's phenomenon, mechanic's hand, and anti PL-7 antibody (threonyl-tRNA synthetase antibody). All of these signs were consistent with antisynthetase syndrome. His chest radiograph revealed bilateral hilar lymphadenopathy. Biopsy specimens from his mediastinal lymph node and muscle showed noncaseating epithelioid cell granulomas. Lung histology revealed nonspecific interstitial pneumonia. Antisynthetase syndrome associated with sarcoidosis was diagnosed. Interstitial pneumonia in this patient responded well to high-dose corticosteroid therapy.
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ISSN:0918-2918
1349-7235
1349-7235
DOI:10.2169/internalmedicine.45.1772