Association of swine leukocyte antigen class II haplotypes and immune-related traits in a swine line selected for resistance to mycoplasmal pneumonia

• Published in: Comparative immunology, microbiology and infectious diseases Vol. 48; pp. 33 - 40
• Main Authors: Ando, Asako, Shigenari, Atsuko, Kojima-Shibata, Chihiro, Nakajoh, Mitsuru, Suzuki, Keiichi, Kitagawa, Hitoshi, Shiina, Takashi, Inoko, Hidetoshi, Uenishi, Hirohide
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2016
• Subjects: Allergy and Immunology; Animals; Breeding; Disease association; Disease Resistance - genetics; Genetic Markers; Genotype; Haplotype; Haplotypes; Histocompatibility Antigens Class II - genetics; Histocompatibility Antigens Class II - immunology; Hydrocortisone - blood; Infectious Disease; Leukocyte Count; Mycoplasmal pneumonia; Phagocytosis; Phenotype; Pneumonia of Swine, Mycoplasmal - genetics; Pneumonia of Swine, Mycoplasmal - immunology; Pneumonia of Swine, Mycoplasmal - microbiology; Pneumonia of Swine, Mycoplasmal - physiopathology; Polymorphism, Genetic; Swine - immunology; Swine leukocyte antigen; DG; BF; SRBC; MHC; SLA; high-resolution SLA haplotype; major histocompatibility complex; body weight; MPS; BW; mycoplasmal pneumonia of swine; number of white blood cells; WBC; PCR-sequence-based typing; mycoplasmal pneumonia; haplotype; back fat thickness; Lr; COR; Hp; daily gain; disease association; genotype; sheep red blood cells; PCR-SBT; plasma cortisol concentration; low-resolution SLA haplotype; swine leukocyte antigen; Mycoplasmal pneumonia; Swine leukocyte antigen; Genotype; PCR–SSOP; Disease association; Haplotype
• ISSN: 0147-9571; 1878-1667
• DOI: 10.1016/j.cimid.2016.07.004

Highlights • We examined association of swine MHC (SLA) class II haplotypes with traits in pigs. • The line studied had improved resistance to mycoplasmal pneumonia of swine (MPS). • Two haplotypes showed increased frequency and decreased MPS lesions. • Two haplotypes, associated with increased MPS lesions, decreased in frequency. • SLA class II haplotypes are useful markers for breeding to decrease MPS lesions.