COMPARATIVE EFFECTS OF CEFPIROME (HR 810) AND OTHER CEPHALOSPORINS ON EXPERIMENTALLY INDUCED PNEUMONIA IN MICE

• Published in: Journal of antibiotics Vol. 39; no. 7; pp. 971 - 977
• Main Authors: KLESEL, N., ISERT, D., LIMBERT, M., SEIBERT, G., WINKLER, I., SCHRINNER, E.
• Format: Journal Article
• Language: English
• Published: Tokyo JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 1986; Japan Antibiotics Research Association
• Subjects: Animals; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Biological and medical sciences; Cefpirome; Cephalosporins - metabolism; Cephalosporins - pharmacology; Cephalosporins - therapeutic use; Klebsiella Infections - drug therapy; Klebsiella pneumoniae - drug effects; Lung - metabolism; Male; Medical sciences; Mice; Mice, Inbred Strains; Pharmacology. Drug treatments; Pneumonia - drug therapy; Pneumonia; Respiratory disease; Rodentia; Lactam; Cephalosporin; Infection; Vertebrata; Antibiotic; Chemotherapy; Mammalia; Mouse; Animal; Bacteriosis; Bacteria; Antibacterial agent; Klebsielleae; Comparative study; Klebsiella pneumoniae; Enterobacteriaceae
• ISSN: 0021-8820; 1881-1469
• DOI: 10.7164/antibiotics.39.971

The chemotherapeutic efficacy of cefpirome (HR 810), a new polar aminothiazolylcephalosporin and that of ceftazidime, cefotaxime, cefoperazone, latamoxef and cefodizime were examined against experimental pneumonia caused by Klebsiella pneumoniae DT-S in mice. When compared in terms of MIC values against the infecting organism and the pharmacokinetic pattern, cefpirome showed equal activity and a similar pharmacokinetic behavior to ceftazidime and cefotaxime in mice. Trials to assess the bactericidial activity in vivo, however, showed that cefpirome displayed a more marked bactericidal effect in pneumonic mice than the other cephalosporins tested. Only cefodizime, a cephalosporin with extremely high and prolonged blood and tissue levels in experimental animals exerted chemotherapeutic effects similar to cefpirome. After cefpirome or cefodizime medication (50mg/kg), the viable counts in the lungs of experimental animals fell steadily to 1/10, 000 of the pretreatment level and, in contrast to the reference compounds, no regrowth of the challenge organisms could be observed with both drugs. Moreover, with ED50s ranging from 1.1 to 59.1mg/kg in treatment studies, cefpirome as well as cefodizime were two to ten times more effective than ceftazidime and cefotaxime, whereas cefoperazone and latamoxef were considerably less effective.