PneuMum: Impact from a randomised controlled trial of maternal 23-valent pneumococcal polysaccharide vaccination on middle ear disease amongst Indigenous infants, Northern Territory, Australia
Highlights • We achieved our intended sample size of 210 participants. • Rates of ear disease (71%) and 23vPPV-type carriage (26%) were lower than expected. • We were unable to show maternal 23vPPV efficacy against infant ear disease or 23vPPV-type carriage. • 23vPPV in pregnancy halved infant ear d...
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Published in | Vaccine Vol. 33; no. 48; pp. 6579 - 6587 |
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Main Authors | , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier Ltd
27.11.2015
Elsevier Limited |
Subjects | |
Online Access | Get full text |
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Summary: | Highlights • We achieved our intended sample size of 210 participants. • Rates of ear disease (71%) and 23vPPV-type carriage (26%) were lower than expected. • We were unable to show maternal 23vPPV efficacy against infant ear disease or 23vPPV-type carriage. • 23vPPV in pregnancy halved infant ear disease concurrent with 23vPPV-type carriage. • 23vPPV in pregnancy may complement childhood pneumococcal vaccination programs. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-News-3 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0264-410X 1873-2518 |
DOI: | 10.1016/j.vaccine.2015.10.101 |