PneuMum: Impact from a randomised controlled trial of maternal 23-valent pneumococcal polysaccharide vaccination on middle ear disease amongst Indigenous infants, Northern Territory, Australia

• Published in: Vaccine Vol. 33; no. 48; pp. 6579 - 6587
• Main Authors: Binks, Michael J, Moberley, Sarah A, Balloch, Anne, Leach, Amanda J, Nelson, Sandra, Hare, Kim M, Wilson, Cate, Morris, Peter S, Nelson, Jane, Chatfield, Mark D, Tang, Mimi L.K, Torzillo, Paul, Carapetis, Jonathan R, Mulholland, E. Kim, Andrews, Ross M
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 27.11.2015; Elsevier Limited
• Subjects: 23-valent pneumococcal polysaccharide vaccine; Adolescent; Adult; Allergy and Immunology; Australia; Babies; Carrier State - epidemiology; Carrier State - immunology; Carrier State - prevention & control; Ear diseases; Female; Humans; Immunity, Maternally-Acquired; Immunization; Indigenous; Infant; Infants; Nasopharynx - microbiology; Northern Territory - epidemiology; Oceanic Ancestry Group; Otitis media; Otitis Media - epidemiology; Otitis Media - immunology; Otitis Media - microbiology; Otitis Media - prevention & control; Pneumococcal Infections - epidemiology; Pneumococcal Infections - prevention & control; Pneumococcal Vaccines - administration & dosage; Pneumococcal Vaccines - immunology; Pneumococcus; Pneumonia; Pregnancy; Prevalence; Streptococcus pneumoniae; Streptococcus pneumoniae - immunology; Streptococcus pneumoniae - isolation & purification; Vaccination; Vaccines; Young Adult; Northern Territory; Australia; Pregnancy; Otitis media; Australia; Indigenous; Pneumococcus; 23-valent pneumococcal polysaccharide vaccine
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2015.10.101

Highlights • We achieved our intended sample size of 210 participants. • Rates of ear disease (71%) and 23vPPV-type carriage (26%) were lower than expected. • We were unable to show maternal 23vPPV efficacy against infant ear disease or 23vPPV-type carriage. • 23vPPV in pregnancy halved infant ear disease concurrent with 23vPPV-type carriage. • 23vPPV in pregnancy may complement childhood pneumococcal vaccination programs.