Group 2 Innate Lymphoid Cells in Human Respiratory Disorders

Recent studies using animal models have generated profound insight into the functions of various subsets of innate lymphoid cells (ILCs). The group 2 ILC subset (ILC2) has been implicated in tissue homeostasis, defense responses against parasites, tissue repair, and immunopathology associated with t...

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Published inJournal of innate immunity Vol. 12; no. 1; pp. 47 - 62
Main Authors van der Ploeg, Esmee K., Carreras Mascaro, Ana, Huylebroeck, Danny, Hendriks, Rudi W., Stadhouders, Ralph
Format Journal Article
LanguageEnglish
Published Basel, Switzerland S. Karger AG 01.01.2020
Subjects
Animals
Cell Differentiation
Cell Plasticity
Cytokines - metabolism
Disease Models, Animal
Humans
Immunity, Innate
Lung Diseases - immunology
Lymphocytes - immunology
Review
Review Article
Th2 Cells - immunology
ILC2
Allergy
Lung
Innate lymphoid cell
Plasticity
Asthma
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Summary:Recent studies using animal models have generated profound insight into the functions of various subsets of innate lymphoid cells (ILCs). The group 2 ILC subset (ILC2) has been implicated in tissue homeostasis, defense responses against parasites, tissue repair, and immunopathology associated with type-2 immunity. In addition, progress has also been made in translating these findings from animal studies into a context of human immunity. Importantly, recent observations strongly support a role for ILC2s in several diseases of the human respiratory system. However, many aspects of human ILC2 biology are still unclear, including how these cells develop and which signals control their activity. As a result, the exact role played by ILCs in human health and disease remains poorly understood. Here, we summarize our current understanding of human ILC2 biology and focus on their potential involvement in various human respiratory disorders.
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ISSN:1662-811X
1662-8128
DOI:10.1159/000496212