Parallel palaeogenomic transects reveal complex genetic history of early European farmers

• Published in: Nature (London) Vol. 551; no. 7680; pp. 368 - 372
• Main Authors: Lipson, Mark, Szécsényi-Nagy, Anna, Mallick, Swapan, Pósa, Annamária, Stégmár, Balázs, Keerl, Victoria, Rohland, Nadin, Stewardson, Kristin, Ferry, Matthew, Michel, Megan, Oppenheimer, Jonas, Broomandkhoshbacht, Nasreen, Harney, Eadaoin, Nordenfelt, Susanne, Llamas, Bastien, Gusztáv Mende, Balázs, Köhler, Kitti, Oross, Krisztián, Bondár, Mária, Marton, Tibor, Osztás, Anett, Jakucs, János, Paluch, Tibor, Horváth, Ferenc, Csengeri, Piroska, Koós, Judit, Sebők, Katalin, Anders, Alexandra, Raczky, Pál, Regenye, Judit, Barna, Judit P., Fábián, Szilvia, Serlegi, Gábor, Toldi, Zoltán, Gyöngyvér Nagy, Emese, Dani, János, Molnár, Erika, Pálfi, György, Márk, László, Melegh, Béla, Bánfai, Zsolt, Domboróczki, László, Fernández-Eraso, Javier, Antonio Mujika-Alustiza, José, Alonso Fernández, Carmen, Jiménez Echevarría, Javier, Bollongino, Ruth, Orschiedt, Jörg, Schierhold, Kerstin, Meller, Harald, Cooper, Alan, Burger, Joachim, Bánffy, Eszter, Alt, Kurt W., Lalueza-Fox, Carles, Haak, Wolfgang, Reich, David
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 16.11.2017; Nature Publishing Group
• Subjects: 45/22; 45/23; 631/181/19/27; 631/208/457; Datasets as Topic; Deoxyribonucleic acid; DNA; DNA, Ancient - analysis; Farmers; Farmers - history; Female; Gene flow; Gene Flow - genetics; Genetic aspects; Genetic diversity; Genetic transformation; Genetic Variation; Genomes; Germany; History, Ancient; Human Migration - history; Humanities and Social Sciences; Humans; Hungary; Hunter-gatherers; letter; Male; multidisciplinary; Natural history; Neolithic; Paleontology; Population Dynamics; Population genetics; Populations; Principal components analysis; Science; Spain; Spatio-Temporal Analysis; Stone Age; Studies; Europe; Hungary; Germany; Spain
• ISSN: 0028-0836; 1476-4687
• DOI: 10.1038/nature24476

In European Neolithic populations, the arrival of farmers prompted admixture with local hunter-gatherers over many centuries, resulting in distinct signatures in each region due to a complex series of interactions. Early European union of farmers David Reich and colleagues analyse genome-wide data from 180 individuals from the Neolithic and Chalcolithic periods of Hungary, Germany and Spain to study the population dynamics of Neolithization in European prehistory. They examine how gene flow reshaped European populations during the Neolithic period, including pervasive admixture—the interbreeding between previously isolated populations—between groups with different ancestry profiles. In each region, they find that the arrival of farmers prompted admixture with local hunter-gatherers, over the course of 3,000 years. Ancient DNA studies have established that Neolithic European populations were descended from Anatolian migrants 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 who received a limited amount of admixture from resident hunter-gatherers 3 , 4 , 5 , 9 . Many open questions remain, however, about the spatial and temporal dynamics of population interactions and admixture during the Neolithic period. Here we investigate the population dynamics of Neolithization across Europe using a high-resolution genome-wide ancient DNA dataset with a total of 180 samples, of which 130 are newly reported here, from the Neolithic and Chalcolithic periods of Hungary (6000–2900 bc , n  = 100), Germany (5500–3000 bc , n  = 42) and Spain (5500–2200 bc , n  = 38). We find that genetic diversity was shaped predominantly by local processes, with varied sources and proportions of hunter-gatherer ancestry among the three regions and through time. Admixture between groups with different ancestry profiles was pervasive and resulted in observable population transformation across almost all cultural transitions. Our results shed new light on the ways in which gene flow reshaped European populations throughout the Neolithic period and demonstrate the potential of time-series-based sampling and modelling approaches to elucidate multiple dimensions of historical population interactions.