Luteolin enhances oxidative stress tolerance via the daf-16 pathway in the nematode Caenorhabditis elegans

Luteolin, widely present in plants, has various physiological functions. Here, we aimed to investigate whether luteolin affects lifespan and oxidative stress tolerance using Caenorhabditis elegans. Luteolin had no effect on the lifespan of wild-type N2 worms under normal conditions. In contrast, lut...

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Published inFood Science and Technology Research Vol. 30; no. 2; pp. 253 - 260
Main Authors Yamamoto, Ryoko, Takahashi, Eriko, Harada, Maho, Sawahata, Izumi, Nishizuka, Makoto
Format Journal Article
LanguageEnglish
Published Tsukuba Japanese Society for Food Science and Technology 01.01.2024
Japan Science and Technology Agency
Subjects
Caenorhabditis elegans
Cytotoxicity
daf-16
Gene expression
Life span
lifespan
luteolin
Lymphocytes T
MnSOD gene
Oxidative stress
Prolongation
Sod
Worms
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Abstract Luteolin, widely present in plants, has various physiological functions. Here, we aimed to investigate whether luteolin affects lifespan and oxidative stress tolerance using Caenorhabditis elegans. Luteolin had no effect on the lifespan of wild-type N2 worms under normal conditions. In contrast, luteolin prolonged the lifespan of N2 worms under oxidative stress, suggesting that luteolin enhances oxidative stress tolerance. Luteolin upregulated the expression of gst-4, sod-1, sod-2, sod-3, and ctl-3 in N2 worms under oxidative stress conditions. The expression of these genes was regulated by DAF-16. Prolongation of lifespan and induction of gene expression by luteolin under oxidative stress conditions were not seen in daf-16 (mu86) mutants. These results suggest that the enhancement of oxidative stress tolerance by luteolin was mediated by the daf-16 pathway in C. elegans.
AbstractList Luteolin, widely present in plants, has various physiological functions. Here, we aimed to investigate whether luteolin affects lifespan and oxidative stress tolerance using Caenorhabditis elegans. Luteolin had no effect on the lifespan of wild-type N2 worms under normal conditions. In contrast, luteolin prolonged the lifespan of N2 worms under oxidative stress, suggesting that luteolin enhances oxidative stress tolerance. Luteolin upregulated the expression of gst-4, sod-1, sod-2, sod-3, and ctl-3 in N2 worms under oxidative stress conditions. The expression of these genes was regulated by DAF-16. Prolongation of lifespan and induction of gene expression by luteolin under oxidative stress conditions were not seen in daf-16 (mu86) mutants. These results suggest that the enhancement of oxidative stress tolerance by luteolin was mediated by the daf-16 pathway in C. elegans.
ArticleNumber FSTR-D-23-00176
Author Harada, Maho
Takahashi, Eriko
Yamamoto, Ryoko
Sawahata, Izumi
Nishizuka, Makoto
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10.1021/acs.jafc.7b05700
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SubjectTerms Caenorhabditis elegans
Cytotoxicity
daf-16
Gene expression
Life span
lifespan
luteolin
Lymphocytes T
MnSOD gene
Oxidative stress
Prolongation
Sod
Worms
Title Luteolin enhances oxidative stress tolerance via the daf-16 pathway in the nematode Caenorhabditis elegans
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