Silencing of the Aspergillopepsin B (pepB) Gene of Aspergillus awamori by Antisense RNA Expression or Protease Removal by Gene Disruption Results in a Large Increase in Thaumatin Production

• Published in: Applied and Environmental Microbiology Vol. 68; no. 7; pp. 3550 - 3559
• Main Authors: Moralejo, Francisco J., Cardoza, Rosa Elena, Gutierrez, Santiago, Lombraña, Marta, Fierro, Francisco, Martín, Juan F.
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.07.2002
• Subjects: antisense RNA; Aspergillus; Aspergillus - drug effects; Aspergillus - genetics; Aspergillus - metabolism; Aspergillus awamori; Bacterial Proteins; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Biological and medical sciences; biosynthesis; Biotechnology; Chromosomes, Bacterial; Culture Media; Down-Regulation; drug effects; Endopeptidases; Endopeptidases - metabolism; enzyme activity; Fundamental and applied biological sciences. Psychology; Gene Dosage; gene expression; Gene Silencing; Gene Silencing - drug effects; Genetic engineering; Genetic technics; genetically modified organisms; genetics; Genetics and Molecular Biology; Hydrogen-Ion Concentration; metabolism; Methods. Procedures. Technologies; Microbiology; Modification of gene expression level; pharmacology; Plant Proteins; Plant Proteins - metabolism; protein degradation; proteinases; RNA, Antisense; RNA, Antisense - biosynthesis; RNA, Antisense - pharmacology; sweet-tasting compounds; Sweetening Agents; Transcription, Genetic; Recombinant microorganism; Thaumatin; Enzyme; Antisense RNA; Fungi; Peptidases; Gene silencing; Gene; Production; Deletion; Hydrolases; Fungi Imperfecti; Thallophyta; Aspergillus awamori
• ISSN: 0099-2240; 1098-5336
• DOI: 10.1128/AEM.68.7.3550-3559.2002

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