Activation of fast sleep spindles at the premotor cortex and parietal areas contributes to motor learning: A study using sLORETA

• Published in: Clinical neurophysiology Vol. 120; no. 5; pp. 878 - 886
• Main Authors: Tamaki, Masako, Matsuoka, Tatsuya, Nittono, Hiroshi, Hori, Tadao
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ireland Ltd 01.05.2009; Elsevier
• Subjects: Adult; Biological and medical sciences; Brain Mapping - methods; Electrodiagnosis. Electric activity recording; Evoked Potentials - physiology; Fast spindle; Female; Frontal Lobe - anatomy & histology; Frontal Lobe - physiology; Fundamental and applied biological sciences. Psychology; Humans; Investigative techniques, diagnostic techniques (general aspects); Learning; Learning - physiology; Magnetoencephalography - methods; Male; Medical sciences; Memory; Motor Cortex - physiology; Movement - physiology; Nerve Net - physiology; Nervous system; Neurology; Neuronal Plasticity - physiology; Neuropsychological Tests; Parietal associative area; Parietal Lobe - anatomy & histology; Parietal Lobe - physiology; Photic Stimulation; Premotor cortex; Psychomotor Performance - physiology; Sleep; Sleep - physiology; Sleep spindle; Sleep. Vigilance; Thalamus - physiology; Time Factors; Vertebrates: nervous system and sense organs; Young Adult; Learning; Fast spindle; Sleep; Memory; Premotor cortex; Sleep spindle; Parietal associative area; Human; Memory disorder; Cognitive disorder; Motor pathway; Central nervous system; Motor learning; Encephalon; Electrodiagnosis; Acquisition process; Parietal cortex; Synaptic plasticity; Sleep wake cycle; Motricity; Current density
• ISSN: 1388-2457; 1872-8952
• DOI: 10.1016/j.clinph.2009.03.006

Abstract Objective The present study examined whether slow and/or fast sleep spindles are related to visuomotor learning, by examining the densities of current sleep spindle activities. Methods Participants completed a visuomotor task before and after sleep on the learning night. This task was not performed on the non-learning night. Standard polysomnographic recordings were made. After the amplitudes of slow and fast spindles were calculated, sLORETA was used to localize the source of slow and fast spindles and to investigate the relationship between spindle activity and motor learning. Results Fast spindle amplitude was significantly larger on the learning than on the non-learning nights, particularly at the left frontal area. sLORETA revealed that fast spindle activities in the left frontal and left parietal areas were enhanced when a new visuomotor skill was learned. There were no significant learning-dependent changes in slow spindle activity. Conclusions Fast spindle activity increases in cortical areas that are involved in learning a new visuomotor skill. The thalamocortical network that underlies the generation of fast spindles may contribute to the synaptic plasticity that occurs during sleep. Significance Activity of fast sleep spindles is a possible biomarker of memory deficits.