Cytoarchitecture of the olfactory bulb in the laggard mutant mouse

• Published in: Neuroscience Vol. 275; pp. 259 - 271
• Main Authors: Yunus, J, Setsu, T, Kikkawa, S, Sakisaka, T, Terashima, T
• Format: Journal Article
• Language: English
• Published: United States 05.09.2014
• Subjects: Animals; Apoptosis - physiology; Fluorescent Antibody Technique; Immunohistochemistry; In Situ Nick-End Labeling; Kinesin - genetics; Mice; Mice, Mutant Strains; Mutation; Neurogenesis - genetics; Neurology; Neurons - pathology; Olfactory Bulb - pathology; Olfactory Pathways - cytology; Triticum aestivum; EPL; olfactory nerve layer; mitral cell layer; phosphate-buffered solution; 3,3′-diaminobenzidine; apoptosis; phosphate-buffered saline; glomerular layer; hematoxylin-eosin; ONL; BSA; TUNEL; Kif14; MBP; laggard; rostral migratory stream; PBS; olfactory bulb; development; DAB; GL; WGA-HRP; granule cell layer; terminal deoxynucleotidyl transferase dUTP nick end labeling; myelin basic protein; GFAP; tyrosine hydroxylase; wheat germ agglutinin-horseradish peroxidase; GCL; PB; TH; PRC1; external plexiform layer; MCL; RMS; protein regulator of cytokinesis 1; glial fibrillary acidic protein; HE; bovine serum albumin
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2014.06.011

Highlights • The olfactory bulb of the laggard ( lag ) mouse, caused by mutation in Kif14 gene, is cytoarchitecturally disorganized. • The rostral migratory stream of the laggard mouse becomes gradually thinner or obliterated during early postnatal days. • Some of mitral cells and periglomerular cells in the olfactory bulb of the laggard mouse are multinucleated. • TUNEL-positive cells in the olfactory bulb of the laggard mouse are increased during late embryological days.