Altered Feedback-Related Negativity in Mild Cognitive Impairment

• Published in: Brain sciences Vol. 13; no. 2; p. 203
• Main Authors: Abe, Satoshi, Onoda, Keiichi, Takamura, Masahiro, Nitta, Eri, Nagai, Atsushi, Yamaguchi, Shuhei
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25.01.2023; MDPI
• Subjects: Age; Alzheimer's disease; Apathy; Brain research; Cognitive ability; Dementia; Dementia disorders; EEG; Electroencephalography; event-related brain potentials; Executive function; Feedback; feedback-related negativity; Latency; Memory; mild cognitive impairment; Neurodegenerative diseases; Neuropsychology; Psychological assessment; Punishment; Reaction time task; Software; Statistical analysis; Japan; Germany; event-related brain potentials; mild cognitive impairment; feedback-related negativity
• ISSN: 2076-3425; 2076-3425
• DOI: 10.3390/brainsci13020203

Feedback-related negativity (FRN) is electrical brain activity related to the function of monitoring behavior and its outcome. FRN is generated by negative feedback input, such as punishment or monetary loss, and its potential is distributed maximally over the frontal-central part of the skull. Our previous study demonstrated that FRN latency was delayed and that the amplitude was increased in patients with mild Alzheimer's disease (AD). As mild cognitive impairment (MCI) is considered to be a prodromal stage of AD, we speculated that FRN would also be altered in MCI, as in AD. The aim of this study is to examine whether MCI patients showed changes in FRN during a gambling task. Thirteen MCI patients and thirteen age-matched healthy elderly individuals participated in a simple gambling task and underwent neuro-psychological assessments. The participants were asked to choose one out of two options and randomly received positive or negative feedback to their response. An EEG was recorded during the task, and FRN was obtained by subtracting the positive feedback-related activity from the negative feedback-related activity. The reaction time to probe stimuli was comparable in the two groups. The group comparisons revealed that the FRN amplitude was significantly larger for the MCI group than for the healthy elderly ( (1,24) = 6.4, η = 0.22, = 0.019), but there was no group difference in the FRN latency. The FRN amplitude at the frontocentral electrode positively correlated with the mini-mental state examination score ( = 0.41, = 0.043). The finding of increased FRN amplitude in MCI was consistent with the previous finding in AD. Our findings indicate that monitoring dysfunction might also be involved in the prodromal stage of dementia.