Current mouse models of oral squamous cell carcinoma: Genetic and chemically induced models

• Published in: Oral oncology Vol. 73; pp. 16 - 20
• Main Authors: Ishida, Kazuhisa, Tomita, Hiroyuki, Nakashima, Takayuki, Hirata, Akihiro, Tanaka, Takauji, Shibata, Toshiyuki, Hara, Akira
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2017
• Subjects: Animals; Carcinogens - toxicity; Carcinoma, Squamous Cell - chemically induced; Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - pathology; Disease Models, Animal; Disease Progression; Genetically modified mouse; Heterografts; Humans; Mice; Mice, Transgenic; Mouse model; Mouth Neoplasms - chemically induced; Mouth Neoplasms - genetics; Mouth Neoplasms - pathology; Oral cavity; Squamous cell carcinoma; Oral cavity; Squamous cell carcinoma; Mouse model; Genetically modified mouse
• ISSN: 1368-8375; 1879-0593; 1879-0593
• DOI: 10.1016/j.oraloncology.2017.07.028

•There is a few suitable mouse models in oral squamous cell carcinoma (OSCC).•The 4NQO-induced mouse model phenocopies the human OSCC.•Genetically engineered mouse models can clarify the molecular pathogenesis of OSCC. Oral squamous cell carcinoma (OSCC) patients have a low 5-year survival rate and poor prognosis. To improve survival and prognosis, the causes and processes involved in lesion development should be evaluated. For this purpose, the use of OSCC mouse models, such as chemically induced mouse models, genetically modified mouse models, and transplanted (xenograft) models, is crucial. These OSCC models exhibit both advantages and disadvantages when studying OSCC development and progression. Until a model resembling human OSCC is developed, both the advantages and disadvantages of each model should be carefully considered. In this review, we discuss OSCC mouse models and their use in cancer research worldwide.