Material property estimation for tubes and arteries using ultrasound radiation force and analysis of propagating modes

• Published in: The Journal of the Acoustical Society of America Vol. 129; no. 3; p. 1344
• Main Authors: Bernal, Miguel, Nenadic, Ivan, Urban, Matthew W, Greenleaf, James F
• Format: Journal Article
• Language: English
• Published: United States 01.03.2011
• Subjects: Animals; Blood Pressure; Carotid Arteries - diagnostic imaging; Compliance; Elastic Modulus; Elasticity Imaging Techniques - instrumentation; Elasticity Imaging Techniques - methods; Fourier Analysis; Gelatin; Image Interpretation, Computer-Assisted; Models, Cardiovascular; Phantoms, Imaging; Pulsatile Flow; Swine; Time Factors; Urethane
• ISSN: 1520-8524
• DOI: 10.1121/1.3533735

Arterial elasticity has been proposed as an independent predictor of cardiovascular diseases and mortality. Identification of the different propagating modes in thin shells can be used to characterize the elastic properties. Ultrasound radiation force was used to generate local mechanical waves in the wall of a urethane tube or an excised pig carotid artery. The waves were tracked using pulse-echo ultrasound. A modal analysis using two-dimensional discrete fast Fourier transform was performed on the time-space signal. This allowed the visualization of different modes of propagation and characterization of dispersion curves for both structures. The urethane tube/artery was mounted in a metallic frame, embedded in tissue-mimicking gelatin, cannulated, and pressurized over a range of 10-100 mmHg. The k-space and the dispersion curves of the urethane tube showed one mode of propagation, with no effect of transmural pressure. Fitting of a Lamb wave model estimated Young's modulus in the urethane tube around 560 kPa. Young's modulus of the artery ranged from 72 to 134 kPa at 10 and 100 mmHg, respectively. The changes observed in the artery dispersion curves suggest that this methodology of exciting mechanical waves and characterizing the modes of propagation has potential for studying arterial elasticity.