Immediate Remission Obtained by Minocycline in a Patient with Histiocytic Necrotizing Lymphadenitis

A 29-year-old man was admitted because of fever, arthralgia and swelling of the cervical lymph nodes. A diagnosis of histiocytic necrotizing lymphadenitis (HNL) was made based on the findings of a lymph node biopsy. At first, piperacillin sodium (PIPC) was started, but a spiking fever persisted. We...

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Bibliographic Details
Published inInternal Medicine Vol. 40; no. 10; pp. 1055 - 1058
Main Authors TAKADA, Kunio, SUZUKI, Kimihiro, HIDAKA, Toshihiko, KONISHI, Tatsuya, SHINOHARA, Tadashi, KATAHARADA, Kohji, MATSUMOTO, Mitsuyo, OKADA, Makoto, OHSUZU, Fumitaka
Format Journal Article
LanguageEnglish
Published Tokyo The Japanese Society of Internal Medicine 01.10.2001
Japanese Society of Internal Medicine
Subjects
Adult
Anti-Bacterial Agents - therapeutic use
Biological and medical sciences
Histiocytic Necrotizing Lymphadenitis - drug therapy
Histiocytic Necrotizing Lymphadenitis - pathology
Humans
Kikuchi disease
Kikuchi-Fujimoto disease
lymph node biopsy
Male
Medical sciences
Minocycline - therapeutic use
Remission Induction
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
spiking fever
Time Factors
Human
Tetracycline derivatives
Fever
Inflammatory disease
Case study
Antibiotic
Chemotherapy
Treatment
Adenopathy
Systemic disease
Young adult
Kikuchi Fujimoto disease
Cervical ganglion
Minocycline
Female
Antibacterial agent
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Summary:A 29-year-old man was admitted because of fever, arthralgia and swelling of the cervical lymph nodes. A diagnosis of histiocytic necrotizing lymphadenitis (HNL) was made based on the findings of a lymph node biopsy. At first, piperacillin sodium (PIPC) was started, but a spiking fever persisted. We therefore changed the PIPC treatment to minocycline. On the following day, his clinical and laboratory findings were dramatically improved. After administering minocycline for 10 days, the HNL symptoms completely disappeared. He has been in good health for 3 years since undergoing treatment. This case strongly indicates that minocycline-sensitive microorganism(s) may be related, at least in part, to the etiology of HNL. (Internal Medicine 40: 1055-1058, 2001)
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.40.1055