Translational Mini-Review Series on Vaccines for HIV: Harnessing innate immunity for HIV vaccine development

Innate immunity is critical for shaping vaccine-elicited adaptive immune responses. Several classes of immune sensors, including Toll-like receptors, retinoic acid-inducible gene-I-like receptors, nucleotide-binding oligomerization domain-like receptors and cytosolic DNA receptors mediate important...

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Bibliographic Details
Published inClinical and experimental immunology Vol. 157; no. 2; pp. 174 - 180
Main Authors Rhee, E.G, Barouch, D.H
Format Journal Article
LanguageEnglish
Published Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01.08.2009
Blackwell Publishing Ltd
Blackwell
Blackwell Science Inc
Subjects
Adjuvants, Immunologic
AIDS Vaccines - immunology
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
HIV
HIV Infections - immunology
HIV Infections - prevention & control
HIV-1
Human immunodeficiency virus
Human viral diseases
Humans
immunity
Immunity, Innate
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunologic Memory
Immunopathology
Infectious diseases
innate immunity
Ligands
Medical sciences
Review
TLR
Toll-Like Receptors - immunology
vaccines
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Immunopathology
vaccines
Retroviridae
Natural immunity
Toll like receptor
AIDS
Biochemistry
Vaccine
Review
Immune deficiency
Lentivirus
Genetic translation
Infection
Virus
HIV
innate immunity
Viral disease
Human immunodeficiency virus
TLR
Bibliographic review
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Summary:Innate immunity is critical for shaping vaccine-elicited adaptive immune responses. Several classes of immune sensors, including Toll-like receptors, retinoic acid-inducible gene-I-like receptors, nucleotide-binding oligomerization domain-like receptors and cytosolic DNA receptors mediate important innate immune pathways and provide potential targets for novel adjuvant development. Understanding how innate immunity modulates adaptive immune responses will probably be important for optimizing vaccine candidates. Here, we review recent advances in innate immunity, focusing upon their potential applications in developing adjuvants and vectors for HIV vaccines.
Bibliography:http://dx.doi.org/10.1111/j.1365-2249.2009.03928.x
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OTHER ARTICLE PUBLISHED IN THIS MINI-REVIEW SERIES ON VACCINES FOR HIV T lymphocyte trafficking and vaccine-elicited mucosal immunity. Clin Exp Immunol 2009; 157: doi:10.1111/j.1365-2249.2009.03927.x
ISSN:0009-9104
1365-2249
DOI:10.1111/j.1365-2249.2009.03928.x