Intraoperative fluorescent imaging using indocyanine green for liver mapping and cholangiography

• Published in: Journal of hepato-biliary-pancreatic sciences Vol. 17; no. 5; pp. 590 - 594
• Main Authors: Aoki, Takeshi, Murakami, Masahiko, Yasuda, Daisuke, Shimizu, Yoshinori, Kusano, Tomokazu, Matsuda, Kazuhiro, Niiya, Takashi, Kato, Hirohisa, Murai, Noriyuki, Otsuka, Koji, Kusano, Mitsuo, Kato, Takashi
• Format: Journal Article
• Language: English
• Published: Japan Springer Japan 01.09.2010; Wiley Subscription Services, Inc
• Subjects: Abdominal Surgery; Adult; Aged; anatomical liver resection; Bile; cholangiography; Cholangiography - instrumentation; Cholecystectomy; Coloring Agents; Equipment Design; Female; Gastroenterology; Hepatectomy - methods; Hepatology; Humans; Indocyanine Green; indocyanine green fluorescent imaging; intraoperative cholangiography; Laparoscopes; Laparoscopy; Liver cirrhosis; liver mapping; Liver Neoplasms - diagnosis; Liver Neoplasms - surgery; Male; Medicine; Medicine & Public Health; Middle Aged; Monitoring, Intraoperative - methods; navigation surgery; Reproducibility of Results; Retrospective Studies; Surgery; Surgical Oncology; Topics; Indocyanine green fluorescent imaging; Navigation surgery; Cholangiography; Intraoperative cholangiography; Liver mapping; Anatomical liver resection
• ISSN: 1868-6974; 1868-6982
• DOI: 10.1007/s00534-009-0197-0

Background Preoperative imaging is widely used and extremely helpful in hepatobiliary surgery. However, transfer of preoperative data to a intraoperative situation is very difficult. Surgeons need intraoperative anatomical information using imaging data for safe and precise operation in the field of hepatobiliary surgery. We have developed a new system for mapping liver segments and cholangiograms using intraoperative indocyanine green (ICG) fluorescence under infrared light observation. Method The imaging technique for mapping liver segments and cholangiogram based on ICG fluorescence used an infrared-based navigation system. Eighty one patients with liver tumors underwent hepatectomy from 2006, January to 2009, March. In liver surgery, 1 ml of ICG was injected via the portal vein under observation by the fluorescent imaging system. Fourteen patients were underwent laparoscopic cholecystectomy for chronic cholecystitis with gallstones. In laparoscopic cholecystectomy, 5 ml of ICG was administered intravenously just before operation and the bile duct was observed using the infrared-based navigation system. Result This new technique successfully identified stained subsegments and segments of the liver in 73 of 81 patients (90.1%). Moreover, clear mapping of liver segments was obtained even against a background of liver cirrhosis. Fluorescent cholangiography clearly showed the common bile duct and cystic duct in 10 of 14 patients (71.4%). No adverse reactions to the ICG were encountered. Conclusion Application of this technique allows intraoperative identification of anatomical landmark in hepatobiliary surgery.