Up‐regulation of histone methyltransferase SETDB1 by multiple mechanisms in hepatocellular carcinoma promotes cancer metastasis

• Published in: Hepatology (Baltimore, Md.) Vol. 63; no. 2; pp. 474 - 487
• Main Authors: Wong, Chun‐Ming, Wei, Lai, Law, Cheuk‐Ting, Ho, Daniel Wai‐Hung, Tsang, Felice Ho‐Ching, Au, Sandy Leung‐Kuen, Sze, Karen Man‐Fong, Lee, Joyce Man‐Fong, Wong, Carmen Chak‐Lui, Ng, Irene Oi‐Lin
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health, Inc 01.02.2016
• Subjects: Animals; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - secondary; Cells, Cultured; Disease Progression; Epigenesis, Genetic; Epigenetics; Gene Expression Regulation, Neoplastic; Histone Methyltransferases; Histone-Lysine N-Methyltransferase - genetics; Humans; Liver cancer; Liver Neoplasms - genetics; Liver Neoplasms - pathology; Male; Metastasis; Mice; Mice, Nude; Protein Methyltransferases - genetics; Rodents; Up-Regulation

Epigenetic deregulation plays an important role in liver carcinogenesis. Using transcriptome sequencing, we examined the expression of 591 epigenetic regulators in hepatitis B‐associated human hepatocellular carcinoma (HCC). We found that aberrant expression of epigenetic regulators was a common eve...